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Fig. 4 | Clinical Epigenetics

Fig. 4

From: Parallel profiling of DNA methylation and hydroxymethylation highlights neuropathology-associated epigenetic variation in Alzheimer’s disease

Fig. 4

Two probes within ANK1 are differentially methylated with respect to Braak stage. Shown are beta values for a cg05066959 and b cg11823178 when adjusted for the co-variates of age, sex, and neuron/glia proportion (Y-axis), against Braak stage (X-axis). Purple circles represent 5mC levels, yellow circles represent 5hmC levels, and gray circles represent uC levels. Regression lines are shown for 5mC (purple line), 5hmC (yellow line), and uC (gray line) levels. Solid regression lines indicate P < 0.05, while dashed lines indicate P > 0.05

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