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Table 5 Differentially methylated regions in blood DNA in relation to NO2 exposure (adjusted p value < 0.05 both in DMRcate and in comb-p)

From: Genome-wide DNA methylation and long-term ambient air pollution exposure in Korean adults

Chra

Gene (distance to geneb)

DMRcate

comb-p

Minimum Pg

Start (bpc)

End (bp)

FDRd

#CpGse

Start (bp)

End (bp)

Sidak Pf

#CpGs

1

RUNX3

25291041

25291905

0.005

7 (4)

 

25291584

0.044

6 (3)

0.001

1

RPS6KA1

26855423

26855926

0.006

4 (3)

 

26855765

0.009

3 (3)

9.1E-04

1

TFAP2E

36038468

36039173

2.1E-04

8 (7)

36038701

 

3.3E-04

6 (6)

0.002

1

ARTN

44398868

44399894

5.6E-04

10 (6)

44399363

 

0.012

6 (4)

9.8E-04

1

S100A12 h

153347819

153348305

2.8E-04

2 (2)

  

0.005

 

2.7E-06

1

S100A14

153589528

153590243

0.013

4 (2)

153589781

 

0.047

3 (2)

0.001

1

S100A13

153599479

153600156

0.001

7 (6)

  

6.6E-04

 

0.003

1

ATP8B2

154300117

154300241

6.9E-04

2 (2)

  

0.007

 

3.4E-05

1

LAX1

203733971

203734559

0.004

6 (4)

  

0.002

 

0.002

1

C1orf35

228291118

228291705

0.023

6 (5)

  

0.017

 

0.009

2

ALS2CR11

202483704

202484583

0.007

10 (5)

202484020

 

0.008

7 (5)

0.006

3

AMT

49459143

49460521

1.3E-06

10 (7)

49459855

 

8.3E-05

9 (7)

1.6E-04

3

PPM1L

160475035

160475336

0.002

5 (5)

  

0.003

 

0.002

3

B3GALNT1

160822268

160822911

0.001

8 (5)

 

160822711

0.031

5 (4)

0.003

5

MGAT4B

179230709

179231109

0.002

3 (2)

  

0.006

 

2.5E-04

5

OR2V1 (− 39,287)

180511822

180512070

0.012

2 (2)

  

0.020

 

7.8E-04

6

DUSP22

291687

292823

7.6E-04

9 (8)

291882

 

2.2E-04

8 (7)

0.005

6

TRIM39

30297174

30297627

1.5E-06

11 (9)

  

2.9E-05

 

6.7E-04

6

LTA h

31539539

31540750

1.9E-15

19 (11)

 

31540461

4.5E-07

18 (11)

3.5E-06

6

HLA-DMB

32904074

32905190

1.2E-05

9 (5)

 

32904621

0.001

5 (3)

8.7E-06

6

HLA-DPB2

33083989

33085470

2.5E-06

22 (12)

33084420

 

2.3E-04

21 (11)

0.006

6

TRAF3IP2

111887243

111887834

0.002

2 (2)

  

0.026

 

3.2E-04

6

MLLT4; C6orf124

168227843

168228706

0.001

3 (3)

168228374

 

0.004

2 (2)

6.4E-05

7

UNCX (− 5426)

1266180

1267228

8.2E-04

4 (4)

1266616

 

0.001

3 (3)

2.0E-04

7

EVX1 (− 2589)

27279101

27279575

0.009

3 (2)

  

0.044

 

1.8E-04

7

STEAP2

89840396

89841435

1.9E-05

13 (5)

 

89841214

0.004

12 (5)

2.1E-04

8

CSGALNACT1

19459672

19460243

2.3E-05

7 (5)

  

6.7E-05

 

1.4E-04

8

KIAA0146; CEBPD (−19)

48648112

48649767

7.6E-08

7 (7)

48648813

 

3.9E-09

6 (6)

7.4E-05

8

HEY1

80678770

80679314

0.002

4 (3)

 

80678925

0.026

2 (2)

4.4E-04

8

NDRG1

134307105

134307728

2.3E-05

3 (3)

134307597

 

7.4E-04

2 (2)

3.0E-05

10

HK1

71087924

71088038

0.009

2 (2)

  

0.038

 

2.0E-04

10

LRRC20

72141375

72141924

7.0E-06

5 (3)

 

72141625

0.007

4 (3)

1.2E-05

10

HTRA1

124254773

124254860

0.003

2 (2)

  

0.010

 

1.1E-04

11

IFITM3 (10863)

330536

331179

5.1E-04

5 (3)

  

0.001

 

1.2E-05

11

LMO2

33913187

33914088

9.3E-04

5 (4)

  

3.2E-04

 

7.2E-04

11

ME3 (− 9563)

86142104

86142587

5.1E-04

4 (3)

  

0.012

 

1.0E-04

13

PDX1 (− 1903)

28491326

28492265

0.006

8 (3)

28491409

28491975

0.035

6 (3)

0.001

13

PCDH20

61989203

61990025

6.0E-05

12 (8)

61989701

 

5.3E-04

8 (7)

6.7E-04

13

DAOA (−319,060)

105791890

105792346

0.023

3 (3)

  

0.024

 

0.003

14

DAD1 (−58,286)

22974144

22975521

0.007

6 (5)

22974951

 

0.029

5 (4)

1.2E-04

14

CTSG

25045625

25046121

0.013

3 (3)

  

0.008

 

0.002

14

PLD4 h

105390602

105391263

0.002

3 (2)

105391018

 

0.007

2 (2)

3.0E-06

15

GATM; LOC145663h

45670068

45671708

8.3E-08

17 (7)

45670478

45671347

1.2E-04

14 (7)

6.4E-07

15

TNFAIP8L3

51387571

51387921

0.002

5 (5)

  

0.004

 

9.7E-04

15

FLJ42289

100890441

100891257

8.3E-07

9 (4)

100890907

 

1.0E-05

5 (4)

3.3E-05

16

TMEM8A; LOC100134368

432973

434356

1.3E-05

7 (4)

433439

433825

1.1E-04

5 (4)

1.2E-04

16

CLDN9

3062056

3062975

0.001

8 (6)

3062349

 

8.0E-04

7 (6)

0.005

17

ALOX12

6898738

6900356

6.9E-10

16 (12)

 

6899888

1.9E-08

15 (12)

0.001

17

WNK4

40932199

40932983

0.006

11 (6)

 

40932746

0.005

9 (6)

0.011

17

IGF2BP1

47091521

47092272

0.006

6 (5)

47091978

 

0.042

5 (4)

0.003

17

CCDC57

80084554

80085082

0.003

4 (4)

  

0.001

 

0.002

19

ELANE

855536

856107

4.5E-04

4 (4)

  

6.1E-05

 

2.8E-04

19

FBXO17

39465821

39467258

2.0E-04

9 (6)

 

39466757

6.1E-05

8 (6)

0.003

20

C20orf123

45179157

45179413

0.002

6 (5)

  

0.005

 

0.002

21

RUNX1

36259067

36259797

0.005

5 (4)

 

36259460

0.008

4 (4)

0.003

22

PARVG

44568337

44568812

0.024

9 (5)

  

0.043

 

0.006

22

PRR5

45125218

45126040

0.002

5 (4)

 

45125666

0.005

4 (3)

0.002

  1. Blanked cells in “Start,” “End,” and “#CpGs” for comb-p represent the same information compared to results in DMRcate
  2. aChromosome
  3. bMinimum distance to transcription start site of the mapped gene (base pair)
  4. cPhysical position (base pair, National Center for Biotechnology Information human reference genome assembly Build 37.3)
  5. dBenjamini-Hochberg false discovery rate
  6. eNumber of probes in the region (number of probes having uncorrected p value < 0.05)
  7. fP of Sidak multiple-testing correction
  8. gMinimum p value among uncorrected p-values of CpGs in the region. When either start or end positions were different between DMRs from the two DMR approaches, we used results from DMRcate
  9. hRegion including significant (FDR < 0.05) differentially methylated probes from our epigenome-wide association study