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Table 4 Differentially methylated regions in blood DNA in relation to PM10 exposure (adjusted P < 0.05 both in DMRcate and in comb-p)

From: Genome-wide DNA methylation and long-term ambient air pollution exposure in Korean adults

Chra

Gene (distance to geneb)

DMRcate

comb-p

Minimum Pg

Start (bpc)

End (bp)

FDRd

#CpGse

Start (bp)

End (bp)

Sidak Pf

#CpGs

1

MIB2

1549615

1550031

0.020

5 (4)

  

0.009

 

0.009

2

NOL10 (−22,166)

10687583

10688726

9.4E-05

8 (5)

10687962

10688317

2.6E-05

5 (5)

2.5E-04

2

SNED1

241975035

241976244

0.006

6 (5)

241975756

 

0.015

4 (4)

0.005

3

IL20RB

136676672

136676846

0.007

2 (2)

  

0.011

 

2.5E-04

6

TRIM27

28874479

28875370

9.4E-05

7 (6)

 

28874754

7.3E-04

4 (4)

0.002

6

TRIM39

30297174

30297627

2.3E-08

11 (10)

  

1.1E-07

 

8.4E-04

6

LTA

31539539

31540750

1.3E-11

19 (13)

 

31540461

3.4E-06

18 (12)

4.8E-05

6

TREM1

41254471

41254997

0.018

4 (3)

41254433

 

0.012

5 (3)

1.7E-04

7

FOXK1

4752951

4753002

1.3E-04

3 (3)

  

7.2E-04

 

3.4E-04

8

CSGALNACT1

19459672

19460243

0.003

7 (4)

  

0.001

 

7.8E-04

8

PIWIL2

22131675

22133356

1.2E-04

15 (6)

22132563

 

0.027

13 (5)

3.8E-05

8

KIF13B h

28961315

28961356

2.9E-04

3 (2)

  

0.003

 

1.4E-06

9

C9orf131

35042344

35042395

0.003

2 (2)

  

0.005

 

5.6E-05

10

CAMK1D

12648032

12648338

3.6E-02

3 (2)

 

12648526

0.011

4 (3)

0.002

10

C10orf105

73498624

73498766

0.003

3 (2)

  

0.032

 

2.7E-05

10

PTPRE

129794994

129795003

0.002

2 (2)

  

0.020

 

3.9E-05

15

FLJ42289

100890907

100891257

1.1E-04

5 (4)

100890963

 

0.014

4 (3)

8.8E-05

17

TNRC6C

76036514

76037562

7.3E-05

7 (7)

76037035

 

1.6E-05

6 (6)

0.001

17

CCDC57

80084554

80085082

1.3E-04

4 (4)

  

1.3E-05

 

4.3E-05

19

PRTN3

846117

846354

0.010

3 (3)

  

0.004

 

0.001

19

PRTN3

847943

848071

0.005

4 (4)

  

0.003

 

0.001

19

CALR

13053719

13054718

0.002

5 (4)

13054427

 

0.014

4 (3)

8.3E-05

19

FBXO17

39465821

39466757

0.002

8 (4)

  

0.004

 

6.6E-04

20

STK35

2085157

2085344

0.003

2 (2)

  

0.002

 

1.7E-05

20

SLPI

43882990

43883307

0.004

3 (3)

 

43883546

8.5E-04

4 (4)

9.7E-04

20

C20orf123

45179157

45179413

2.0E-04

6 (5)

  

1.4E-04

 

2.2E-04

21

C21orf81

15352848

15352983

0.013

2 (2)

  

0.012

 

4.7E-04

  1. Blanked cells in “Start,” “End,” and “#CpGs” for comb-p represent the same information compared to results in DMRcate
  2. aChromosome
  3. bMinimum distance to transcription start site of the mapped gene (base pair)
  4. cPhysical position (base pair, National Center for Biotechnology Information human reference genome assembly Build 37.3)
  5. dBenjamini-Hochberg false discovery rate
  6. eNumber of probes in the region (number of probes having uncorrected p value < 0.05)
  7. fP of Sidak multiple-testing correction
  8. gMinimum p value among uncorrected p-values of CpGs in each region. When either start or end positions were different between DMRs from the two DMR approaches, we used results from DMRcate
  9. hRegion including significant (FDR < 0.05) differentially methylated probes from our epigenome-wide association study