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Table 3 Differentially methylated CpGs in blood DNA in relation to NO2 exposure (FDR < 0.05), ordered by chromosomal location

From: Genome-wide DNA methylation and long-term ambient air pollution exposure in Korean adults

Chra

Gene (distance to geneb)

Probe

Positionc

Coefd

SEe

Pf

1

MAN1C1 (− 7282)

cg16396978

25936677

0.008

0.002

3.9E-06

1

ERI3

cg13451048

44820073

0.007

0.001

8.6E-07

1

RPL5

cg02769668

93302925

− 0.003

0.001

3.3E-07

1

WARS2 (− 29,067)

cg06764239

119544772

0.002

3.5E-04

4.3E-06

1

S100A12

cg02901136

153348305

0.012

0.002

2.7E-06

2

STON1 (169)

cg23256664

48757477

− 0.001

3.0E-04

8.9E-07

2

NDUFB3

cg04865026

201936505

0.012

0.002

7.5E-07

2

PLEKHM3

cg09950920

208734940

0.013

0.003

2.7E-07

2

PIKFYVE

cg19351166

209133632

0.008

0.002

5.5E-06

3

CTDSPL

cg12386061

37906586

0.002

4.3E-04

5.5E-06

3

DCBLD2 (122,596)

cg01188562

98637410

− 0.004

0.001

2.0E-06

3

AP2M1

cg17343451

183899704

0.009

0.002

3.3E-06

4

CPLX1

cg16649791

816968

− 0.014

0.003

1.0E-06

4

LINC01097 (− 3902)

cg25913520

13524041

0.002

3.6E-04

2.8E-06

4

LOC641518

cg13775316

109093218

0.002

4.0E-04

6.2E-07

5

DAP (86217)

cg23112301

10765559

− 0.005

0.001

3.8E-06

5

ZNF366

cg21770462

71803219

0.008

0.002

4.7E-06

5

ERAP1 (− 82,414)

cg13625213

95915327

− 0.002

4.0E-04

3.4E-06

5

CDHR2 (− 2294)

cg18194153

175967218

0.010

0.002

1.3E-07

6

LTA

cg11586857

31540136

− 0.007

0.001

3.5E-06

8

PMP2

cg22796481

82353365

− 0.019

0.004

6.7E-07

8

OSR2

cg09607488

99963657

0.007

0.002

4.5E-06

9

RORB

cg04130427

77113915

0.005

0.001

3.7E-06

10

ZNF438

cg10575075

31288634

0.014

0.003

2.0E-06

10

EMX2

cg02420850

119302157

0.002

4.0E-04

6.2E-07

11

TMEM138

cg03370752

61136373

0.010

0.002

5.5E-06

11

SORL1

cg17510957

121466629

0.011

0.002

5.1E-06

12

TEAD4

cg12902426

3068889

0.003

0.001

3.7E-06

12

STK38L

cg05171937g

27396765

0.010

0.002

1.1E-08

12

DDX55

cg13559144

124086193

0.002

4.3E-04

3.0E-06

13

EDNRB

cg23326536

78491199

− 0.003

0.001

1.7E-06

13

IRS2 (−8541)

cg26583725g

110397643

− 0.001

2.3E-04

4.9E-08

14

ITPK1

cg05284742

93552128

0.009

0.002

4.1E-06

14

OTUB2

cg06992688

94491958

0.013

0.003

3.3E-06

14

PLD4

cg15352829

105391018

0.010

0.002

3.0E-06

15

LOC145663

cg04025675

45671028

0.005

0.001

6.3E-07

16

ZCCHC14

cg16727006

87470545

− 0.010

0.002

4.8E-06

17

EFCAB5 (− 2689)

cg22888787

27950276

0.010

0.002

3.9E-07

17

CD300A (− 12,486)

cg00227781

72450036

0.004

0.001

3.0E-06

19

LOC100128675

cg06642503

35597415

− 0.005

0.001

2.9E-06

19

ZNF347

cg15050103

53642858

− 0.008

0.002

3.7E-06

19

ZNF542 (− 28,810)

cg06109293

56850658

0.020

0.004

1.9E-07

20

NKX2-4 (− 3198)

cg27650906

21372807

0.006

0.001

3.1E-07

20

C20orf56

cg06226567g

22559676

0.003

0.001

3.5E-08

21

MORC3

cg01261013

37691747

0.010

0.002

4.1E-06

  1. aChromosome
  2. bDistance to transcription start site of the mapped gene (base pair)
  3. cPhysical position (base pair, National Center for Biotechnology Information human reference genome assembly Build 37.3)
  4. dRegression coefficient from statistical model. Covariates age, sex, cigarette smoking status, pack-years of smoking, BMI, COPD status and estimated cell-type proportions were included in the model. The coefficient can be interpreted as the difference in DNA methylation per 1 ppb NO2 exposure. For example, cg16396978 showed 0.8% methylation increase per 1 ppb NO2 exposure increase. Methylation values range 0–1
  5. eStandard error of regression coefficient
  6. fUncorrected p value
  7. gStatistically significant after Bonferroni multiple-testing correction (1.2E-07)