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Table 2 Differentially methylated CpGs in blood DNA in relation to PM10 exposure (FDR < 0.05), ordered by chromosomal location

From: Genome-wide DNA methylation and long-term ambient air pollution exposure in Korean adults

Chra

Gene (distance to geneb)

Probe

Positionc

Coefd

SEe

Pf

1

NEGR1

cg07721244

72749275

0.004

0.001

1.6E-07

2

ARID5A

cg04722215

97205147

− 0.006

0.001

1.4E-07

3

FOXL2 (− 81,364)

cg21742790

138581702

0.005

0.001

8.6E-07

3

XXYLT1 (− 92,147)

cg04252203

194696866

0.005

0.001

6.7E-07

6

WDR46

cg05454562g

33254447

0.006

0.001

4.3E-09

7

FAM20C (− 5283)

cg16998831

187686

0.008

0.002

3.0E-07

8

KIF13B

cg07023317

28961315

0.008

0.002

1.4E-06

9

AKNA

cg13999433g

117156883

0.007

0.001

3.9E-08

11

SYTL2

cg11691844g

85460604

0.006

0.001

1.1E-07

14

OTUB2

cg06992688

94491958

0.008

0.002

1.0E-06

16

MIR5093 (11,6079)

cg26964426

85455911

0.025

0.005

8.3E-07

18

NPC1

cg12709880

21163172

0.007

0.001

3.8E-07

  1. aChromosome
  2. bDistance to transcription start site of the mapped gene (base pair)
  3. cPhysical position (base pair, National Center for Biotechnology Information human reference genome assembly Build 37.3)
  4. dRegression coefficient from statistical model. Covariates age, sex, cigarette smoking status, pack-years of smoking, BMI, COPD status, and estimated cell-type proportions were included in the model. The coefficient can be interpreted as the difference in DNA methylation per 1 μg/m3 PM10 exposure. For example, cg07721244 showed 0.4% methylation increase per 1 μg/m3 PM10 exposure increase. Methylation values range 0–1
  5. eStandard error of regression coefficient
  6. fUncorrected p value
  7. gStatistically significant after Bonferroni multiple-testing correction (1.2E-07)