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Table 3 Comparison of liver function tests and tumor markers between CCA and other biliary diseases

From: Serum cell-free DNA methylation of OPCML and HOXD9 as a biomarker that may aid in differential diagnosis between cholangiocarcinoma and other biliary diseases

Parameter

Other biliary (mean ± SD)

CCA (mean ± SD)

P value

Liver function tests

  Cholesterol

203.1 ± 84.44

194.0 ± 54.10

0.565

  Total protein

7.12 ± 0.98

7.41 ± 1.23

0.252

  Albumin

3.65 ± 0.65

3.76 ± 0.64

0.443

  Globulin

3.48 ± 0.69

3.6 ± 0.91

0.535

  Total bilirubin

6.64 ± 10.82

4.16 ± 15.48

0.408

  Direct bilirubin

5.24 ± 8.64

2.84 ± 10.17

0.258

  ALT

70.15 ± 71.91

60.40 ± 52.13

0.489

  AST

99.85 ± 125.2

114.1 ± 226.5

0.729

  ALP

300.9 ± 400.2

187.8 ± 149.8

0.098

Tumor markers

  CA19–9

364.3 ± 430.5

415.2 ± 418.8

0.628

  CEA

38.26 ± 181.7

53.76 ± 178.9

0.738