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Table 5 Summary of KEGG pathway annotation of the 12 identified most significant miRNA targets (DAVID 6.8)a

From: Association of recurrent venous thromboembolism and circulating microRNAs

Pathways

Genes involved in the pathway

p valueb

Pathways in cancer (JAK-STAT pathway and ERK signaling pathway) [38]

69

1.4E-24

TNF signaling pathway [70]

26

5.4E-12

PI3K-Akt signaling pathway [40]

41

8.5E-9

Hippo signaling pathway [43]

26

1.3E-8

TGF-beta signaling pathway [31]

19

3.2E-8

HIF-1 signaling pathway [42]

21

1.3E-8

Focal adhesion [71]

27

9.0E-7

MAPK signaling pathway [41]

26

1.1E-4

Rap1 signaling pathway [39]

23

1.2E-4

  1. aAll the validated predicted miRNA targets (genes listed on Table 4) were run KEGG pathway annotation using the DAVID gene annotation tool
  2. bFisher’s exact p value after Benjamini-Hochberg correction (https://david.ncifcrf.gov/)