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Table 4 Global miRNA target analysis for the 12 identified most significant miRNAs

From: Association of recurrent venous thromboembolism and circulating microRNAs

miRNA name

Number of predicted target genesa

Validated target genesb

hsa-miR-15b-5p

1178

CCNE1, RECK, BCL2, CCND1, IFNG, CHEK1, SMAD7, FOXO1, SMURF1, CRIM1, FGF2, WEE1, FUT2, KDR, HNF1A, AKT3, AGO2, INSR, CCND3, SDCS3, RAB1A, MMP9, RIM14, MTSS1, PEBP4, OIP5, VEGFA, EIF4A1, AXIN2, PURA

hsa-miR-106a-5p

1072

E2F1, VEGFA, TGFBR2, CDKN1A, HIPK3, MYLIP, RB1, APP, RUNX1, ARID4B, VEGFA, IL10, FAS, CYP19A1, PAK5, PTEN, SIRPA, SLC2A3, BMP2, STAT3, CCND1, ATM, RUNX3, TIMP2, MAPK9, LIMK1, FASTK, MAPK14, ULK1, HIF1A, TP53, MSH3, APC, CXCL8, ATG7, IL1B, IL6, TGFB1, TBC1D9, CDX2, MGST2, ERCC1, RND3, RARB, HMGA2, HIPK3, MYLIP, ARID4B, VEGFA, CYP19A1, SIRPA, CASP7, MYB, MFN2

hsa-miR-197-3p

410

TUSC2, NSUN5, CD82, BMF, PMAIP1, MTHFD1, FOXJ2, MAPK1, RAN, TSPAN3, ACVR1

hsa-miR-652-3p

170

LLGL1, ZEB1

hsa-miR-361-5p

298

VEGFA, STAT6, SND1, TWIST1

hsa-miR-222-3p

433

STAT5A, CDKN1B, SOD2, MMP1, FOXO3, CDKN1C, KIT, TMED7, ETS1, PPP2R2A, TIMP3, DIRAS3, FOS, ESR1, BBC3, PTEN, SSSCA1, RECK, TRPS1, CERS2, SSX2IP, DKK2, PHACTR4, rf25, INPP4B, ZFAND5, FAM214A, LYPLA1, TIPARP, TP53BP2, MEGF9, VGLL4, GNAI3, GAS5, PRDM1, GNAI2, SMAD5, RUNX2, FOXO1, BMF, PLXNC1, BCL2L11, DICER1, TNFSF10, ICAM1, SELE, TP53, CORO1A, TCEAL1, DICER1, GRB10, ARID1A, ADAM1A

hsa-miR-26b-5p

1879

SERBP1, PTGS2, EPHA2, ABCA1, ARL4C, GATA4, CHORDC1, NR2C2, TAB1, EZH2, USP9X, KPNA2, RB1, NAMPT, PTEN, COX2, COL1A2, CTGF, TLR4, ST8SIA4, PDE4A, SOCS6, FH, HGF, LARP1, SERBP1, CDK6, CCNE1, PLOD2, IGFR1, MIEN1, ULK2, SMAD1, HAS2, IGF1, JAG1

hsa-miR-532-5p

94

RUNX3, TERT, NKD1, FASN, SYK, TRAPPC2B

hsa-miR-27b-3p

1043

CCNT1, WEE1, ST14, MMP13, ADORA2B, CYP1B1, PPARG, EDNRA, EYA4, VDR, SEMA6A, VEGFC, CREB1, ABCA1, PSAP, LDLR, WNK1, ENDOU, BNIP3, RMND5A, CRISP2, LPIN1, CCNYL1, CAB39L, CPPED1, CNN3, FOXO1, NR2F2, NR5A2, ROR1, CCNG1, FZD7, OSBPL6, CDH11, EGFR, MET, CX3CL1, SOCS6, UCA1, PINK1, NOTCH1, PAX3, CYP3A4, TRAPPC2B, KHSRP, PAX7

hsa-miR-21-5p

644

TGFBR2, TGBR3, TGFB1, RASGRP1, CDC25A, BCK2, RPS7, JAG1, SMRCA4, SPRY2, DUSP10, TIMP3, SOX5, MTAP, DOCK7, DOCK5, RECK, PIAS3, E2F2, PTEN, E2F1, LRRFIP1, CCL20, TPM1, NFIB, APAF1, BTG2, HIPK3, PDCD4, RHOB, ANP32A, SERPINB5, BMPR2, RASA1, MYC, ERBB2, JMY, TOPORS, HNRNPK, DAXX, TP53BP2, TP63, PPIF, MSH2, MSH6, TIAM1, ISCU, EIF4A2, ANKRD46, IL1B, ICAM1, PLAT, CDK2AP1, DOCK4, PPARA, NTF3, COL4A1, FASLG, SMAD7, SOX2, RMND5A, MMP2, VEGFA, SASH1, SERPINI1, DDAH1, PIK3R1, MMP9, ELAVL4, PTPN14, TOR1AIP2, PELI1, YOD1, STAT3, SATB1, WWP1, HPGD, MYD88, IRAK1, VHL, GDF5, IL12A, SECISBP2L, REFL, CXCL10, GAS5, RHO, CASC2, DNM1L, STUB1, LRP6, PSMD9

hsa-miR-103a-3p

780

CAV1, CCNE1, CDK2, CREB1, DICER1, KLF4, CYPC8, ID2, CDK6, MYB, SNCG, OPRM1, AGO1, GPRC5A, SERPINB5, MEF2D, SFRP4, OLFM4, PIEZO1, ADAM10, RUNX2, BNIP3, CACNA1C, GPD1, DAPK1, PTEN, TIMP3, MYCN

hsa-miR-30c-5p

1149

MUC17, UBE2I, SERPINE1, SNAI1, HSPA4, TGIF2, HDAC4, SOCS3, CUL2, NEDD4, SOCS1, ITGB3, ARHGEF6, ITGA4, PIK3R2, MATA1, IL11, DDIT4, DLL4, BCL9, IDH1, RARB, NCOR2, RFX6, RUNX2, CASP3, NOTCH1, TP53, BECN1, MED23, CAMK2D, IER2, CDC42, PAK1, FASN, FOXO3, CTGF, SMAD1, VIM, TWF1, MTTP, SNAI2, EIF2S1, RASAL2

  1. aMiRSystem (http://mirsystem.cgm.ntu.edu.tw/), MiRTarBase (http://mirtarbase.mbc.nctu.edu.tw), and miRDB, version 4.0 (http://mirdb.org)
  2. bValidated with western blot, qPCR, and/or reporter assay