Fig. 7

ADQ inhibits the growth and metastasis of xenograft tumors. a Representative pseudocolor bioluminescence images of mice on days 7, 14, 21, 28, 35, and 42. Mice bearing orthotopic MDA-MB-231 tumors were intraperitoneally injected with PBS or 15 mg/kg ADQ every 2 days. Each group included eight mice (n = 8). b Representative bioluminescence images (BLIs) of PBS- and ADQ-treated tumors. c Tumor volume curves were evaluated. d BLIs of lung metastasis on days 35 and 42. e Representative photomicrographs of H&E-stained lung tissues. f Fluorescence in situ hybridization using 5′ DIG-labeled HOTAIR probes and FITC-labeled EZH2 antibody was performed to detect the HOTAIR/EZH2 binding activity. g NLK expressions were examined by immunohistochemistry in tumor sections