Table 3 Frequency of different pathogeneses in ART patients and Sp patients with PWS stratified according to maternal age
|  | Maternal age ≤ 37 years | Maternal age ≥ 38 years | ||||
|---|---|---|---|---|---|---|
|  | ART patients (n = 12) | Sp patients (n = 215) | P value | ART patients (n = 9) | Sp patients (n = 44) | P value |
UPD(15)mat | 16.7% (2/12) | 9.8% (21/215) | 0.348 | 77.8% (7/9) | 31.8% (14/44) | 0.021 |
Microdeletion at chromosome15q11.5 region | 50.0% (6/12) | 79.5% (171/215) | 0.027 | 0% (0/9) | 36.4% (16/44) | 0.044 |
DNA methylation error | 33.3% (4/12) | 10.7% (23/215) | 0.041 | 22.2% (2/9) | 31.8% (14/44) | 0.706 |