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Table 3 Frequency of different pathogeneses in ART patients and Sp patients with PWS stratified according to maternal age

From: Association of four imprinting disorders and ART

  Maternal age ≤ 37 years Maternal age ≥ 38 years
  ART patients (n = 12) Sp patients (n = 215) P value ART patients (n = 9) Sp patients (n = 44) P value
UPD(15)mat 16.7% (2/12) 9.8% (21/215) 0.348 77.8% (7/9) 31.8% (14/44) 0.021
Microdeletion at chromosome15q11.5 region 50.0% (6/12) 79.5% (171/215) 0.027 0% (0/9) 36.4% (16/44) 0.044
DNA methylation error 33.3% (4/12) 10.7% (23/215) 0.041 22.2% (2/9) 31.8% (14/44) 0.706
  1. All data were obtained from the questionnaire. DNA methylation error indicates gain of methylation at SNRPN-DMR. UPD(15)mat, maternal uniparental disomy of chromosome 15