Fig. 2

Promoters with DMVs in SRS patients. a A Venn diagram showing 83 promoters with DMVs in SRS patients. b Autosomal chromosome frequency (left) and distribution (right) of the promoters with DMVs. Blue bars represent DMVs in ART-SRS patients and red bars represent DMVs in Sp-SRS patients. N.A. indicates that data was not available. c DMVs of promoters in ART-SRS and Sp-SRS patients classified based on methylation of gametes. Sperm-specific methylated regions were ≥ 80% methylated in sperm and ≤ 20% methylated in oocytes, oocyte-specific methylated regions were ≤ 20% methylated in sperm and ≥ 80% methylated in oocytes, both hypermethylated regions were ≥ 80% methylated in both sperm and oocytes, both hypomethylated regions were ≤ 20% methylated in both sperm and oocytes according to our previously reported data [18]