Fig. 1

FLIM-FRET screening identifies potential epigenetic treatment targets. a Schematic illustration of possible ERα-epigenetic biomarker association in a nucleosome scale that facilitates ER-regulated gene transcription. b Typical FLIM images show control (left) and FRET (right) results as lifetime reduces with distance between donor and acceptor fluorophores. c Schematic and prototype of biopsy tissue arrays subjected to FLIM analysis