Discovery and validation of DNA methylation markers for overall survival prognosis in patients with thymic epithelial tumors

Table 3 Results from Cox regression in different populations†

	Univariable Cox regression in whole population		Whole population, adjusted for Masaoka stage		WHO histological type C only, adjusted for age, gender, radiotherapy, and chemotherapy
	HR (95% CI)	P	HR (95% CI)	P	HR (95% CI)	P
cg05784862 KSR1†	0.868 (0.814–0.926)	< 0.001	0.870 (0.814–0.931)	< 0.001	0.852 (0.768–0.945)	0.003
cg07154254 ELF3†	0.718 (0.611–0.844)	< 0.001	0.720 (0.611–0.848)	< 0.001	0.674 (0.519–0.874)	0.003
cg02543462 IL1RN†	0.868 (0.819–0.920)	< 0.001	0.870 (0.819–0.923)	< 0.001	0.859 (0.798–0.925)	< 0.001
cg06288355 RAG1†	1.202 (1.089–1.328)	< 0.001	1.201 (1.085–1.328)	< 0.001	1.201 (1.083–1.332)	0.001

†All beta values in each methylation sites were entered into equation as continuous variables

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