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Fig. 1 | Clinical Epigenetics

Fig. 1

From: Tracking of epigenetic changes during hematopoietic differentiation of induced pluripotent stem cells

Fig. 1

DNA methylation profiles of iPSC-derived hematopoietic progenitor cells. a Schematic representation of the differentiation protocol of iPSCs toward hematopoietic progenitor cells. b Principal component analysis of DNA methylation profiles of our iHPCs (donor 1 and 2) and those of Nishizawa et al. [14], primary CD34+ cells from cord blood (CB) or bone marrow (BM), whole blood, and pluripotent cells. c Scatter plot depicts CpG sites that are either hypermethylated (961 CpG sites, red) or hypomethylated (6075 CpG sites, blue; delta mean β value > 0.5 or < − 0.5) in iHPCs as compared to iPSC (GSE37066). CpG sites associated with promoter regions are highlighted in bold. d Gene ontology analysis of genes with differentially methylated CpG sites in the promoter region. Enrichment of specific categories was calculated by the one-sided Fisher’s exact P value

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