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Table 3 The most associated epigenome-wide significant signals for both periodontal traits

From: Epigenetic findings in periodontitis in UK twins: a cross-sectional study

 

bpa

Annotation

Estimateb

P value

FDR

Genec

Reported traits

Gingival bleeding

CHR2: 185463218

1st exon; 5′ UTR

− 0.33

7.17e−8

0.03

ZNF804A

(Zinc Finger Protein 8)

Bipolar disorder

Schizophrenia

Memory loss

Tooth mobility

CHR7:

2646478

Body

0.38

6.85e−8

2.5e−4

IQCE

(IQ Motif Containing E)

Longevity

Blood metabolite level

CHR8: 11058145

Body

− 0.49

1.53e−8

2.8e−3

XKR6

(XK Related 6)

Asthma

Allergic rhinitis

  1. aCoordinate based on hg19
  2. bEstimate represents the coefficient generated from the epigenetic linear regression model
  3. cGene name derived from UCSC