Table 2 Best fitting models for DNAm age acceleration in young and older twins
From: Leisure-time physical activity and DNA methylation age—a twin study
Additive genetic (a2) | Non-shared environment (e2) | Sex (men vs. women) | BMI | Smoking (former vs. never) | Smoking (current vs. never) | |
|---|---|---|---|---|---|---|
DNAm age acceleration | ||||||
Unadjusted (AE) | ||||||
Young | 0.74* (0.65, 0.81) | 0.26* (0.19, 0.35) | – | – | – | – |
Older | 0.58* (0.45, 0.69) | 0.42* (0.31, 0.55) | – | – | – | – |
Adjusted (AE) | ||||||
Young | 0.74* (0.65, 0.82) | 0.26* (0.19, 0.35) | 0.61 (− 0.16, 1.37) | 0.065 (− 0.01, 0.13) | − 0.23 (− 1.09, 0.64) | − 0.17 (− 0.79, 0.47) |
Older | 0.53* (0.37, 0.65) | 0.47* (0.35, 0.63) | 3.29* (2.00, 4.54) | 0.07 (− 0.03, 0.17) | 0.68 (− 0.32, 1.73) | 0.53 (− 0.84, 1.96) |