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Table 2 Best fitting models for DNAm age acceleration in young and older twins

From: Leisure-time physical activity and DNA methylation age—a twin study

  Additive genetic (a2) Non-shared environment (e2) Sex (men vs. women) BMI Smoking (former vs. never) Smoking (current vs. never)
DNAm age acceleration
 Unadjusted (AE)
  Young 0.74* (0.65, 0.81) 0.26* (0.19, 0.35)
  Older 0.58* (0.45, 0.69) 0.42* (0.31, 0.55)
 Adjusted (AE)
  Young 0.74* (0.65, 0.82) 0.26* (0.19, 0.35) 0.61 (− 0.16, 1.37) 0.065 (− 0.01, 0.13) − 0.23 (− 1.09, 0.64) − 0.17 (− 0.79, 0.47)
  Older 0.53* (0.37, 0.65) 0.47* (0.35, 0.63) 3.29* (2.00, 4.54) 0.07 (− 0.03, 0.17) 0.68 (− 0.32, 1.73) 0.53 (− 0.84, 1.96)
  1. Data are proportion of total variance (95% CI) adjusted for sex, smoking and BMI. *p < 0.001 for young vs. old