Skip to main content
Fig. 5 | Clinical Epigenetics

Fig. 5

From: Maternal obesity influences expression and DNA methylation of the adiponectin and leptin systems in human third-trimester placenta

Fig. 5

DNA methylation in the promoter regions of the ADIPOQ gene. a A schematic representation of the ADIPOQ gene, including the CpG islands in the promoter region. b The methylation pattern in the ADIPOQ promoter region 1 (reg 1) on the fetal and maternal sides of third-trimester placental biopsies from the control group. c The methylation pattern in the ADIPOQ promoter region 2 (reg 2) on the fetal and maternal sides of third-trimester placental biopsies from the control group. d The % methylation level in the ADIPOQ promoter regions in third-trimester placenta. DNA was extracted from third-trimester placental biopsies (on the fetal and maternal sides) in the control and obese women. After bisulfite treatment, the methylation level was determined by pyrosequencing. The data are quoted as the mean ± SEM. **p < 0.01; ***p < 0.001 in a Friedman test. (a) Maternal side vs. fetal side. (b) The obese group vs. the control group

Back to article page