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Table 2 Risks of NTDs associated with methylation level of PAX3 gene in fetal neural tissues

From: Aberrant methylation of Pax3 gene and neural tube defects in association with exposure to polycyclic aromatic hydrocarbons

 

All NTDs

Anencephaly

Spina bifida

ORa (95% CI)

P value

ORa (95% CI)

P value

ORa (95% CI)

P value

Promoter region

0.69 (0.19, 2.45)

0.690

0.68 (0.15, 3.17)

0.683

0.57 (0.11, 2.98)

0.502

 Amplicon_1_CpG_1

0.58 (0.17, 2.04)

0.398

0.44 (0.09, 2.18)

0.444

0.41 (0.07, 2.36)

0.414

 Amplicon_1_CpG_3.4.5

4.24 (1.14, 15.77)

0.031

3.26 (0.56, 18.85)

0.187

4.22 (0.87, 20.56)

0.075

 Amplicon_1_CpG_7

2.49 (0.73, 8.55)

0.146

1.28 (0.26, 6.36)

0.760

5.86 (1.18, 29.10)

0.031

 Amplicon_1_CpG_8.9.10

3.11 (0.87, 11.09)

0.080

3.04 (0.48, 19.36)

0.239

6.57 (1.23, 35.11)

0.028

Body region

6.24 (1.30, 29.97)

0.022

4.30 (0.71, 26.25)

0.114

10.76 (1.06, 109.45)

0.045

 Amplicon_1_CpG_1.2

2.87 (0.81, 10.17)

0.103

2.34 (0.52, 10.51)

0.266

25.16 (1.57, 404.30)

0.023

 Amplicon_1_CpG_3

4.34 (1.12, 16.78)

0.034

4.12 (0.78, 21.89)

0.096

5.15 (0.81, 32.68)

0.082

 Amplicon_1_CpG_4.5.6.7

1.42 (0.40, 5.12)

0.588

1.08 (0.25, 4.72)

0.917

3.35 (0.44, 25.28)

0.241

 Amplicon_1_CpG_8

0.94 (0.16, 5.54)

0.945

0.40 (0.19, 20.06)

0.997

3.98 (0.19, 82.64)

0.372

 Amplicon_1_CpG_10

4.83 (0.99, 23.55)

0.052

2.04 (0.33, 12.65)

0.443

16.95 (1.74, 165.25)

0.015

 Amplicon_1_CpG_11

2.19 (0.61, 7.80)

0.227

0.72 (0.13, 3.90)

0.698

5.30 (0.65, 43.29)

0.120

 Amplicon_1_CpG_13

3.05 (0.83, 11.15)

0.092

1.08 (0.21, 5.55)

0.930

5.23 (1.00, 27.75)

0.050

 Amplicon_1_CpG_14.15

7.52 (1.36, 41.58)

0.021

6.23 (0.86, 45.03)

0.070

6.65 (0.68, 65.51)

0.104

  1. aOR was adjusted by maternal education, occupation, periconceptional folic acid use and fetal sex, gestational age. ORs were in italic when P value < 0.05
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Clinical Epigenetics

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