Table 1 Significantly differentially methylated CpG probes identified in AMD RPE cells
Probe ID | Log2 FC | Adjusted p value | False discovery rate (< 0.2) | Δβ (* > 10%) | Chromosome | Position | Relation to CpG island | UCSC gene name | Relation to gene |
|---|---|---|---|---|---|---|---|---|---|
cg18486102 | 1.81 | 1.08E−12 | 4.6E−07 | *0.20 | chr12 | 50297777 | Island | FAIM2 | TSS200 |
cg18934822 | − 3.00 | 1.18E−09 | 2.5E−04 | *− 0.11 | chr1 | 2191402 | Open Sea | SKI | Body |
cg23169512 | − 3.51 | 2.08E−08 | 2.9E−03 | *− 0.33 | chr15 | 60290666 | N_Shore |  |  |
cg22508626 | 1.02 | 7.03E−07 | 6.0E−02 | *0.12 | chr6 | 30879905 | N_Shore | GTF2H4 | Body |
cg01560972 | − 3.87 | 2.03E−06 | 1.4E−01 | *− 0.33 | chr11 | 8190837 | S_Shore | RIC3 | TSS1500 |
cg26962595 | 1.18 | 2.75E−06 | 1.6E−01 | 0.02 | chr11 | 72504889 | Island | STARD10 | TSS200 |
cg11897517 | 1.67 | 3.87E−06 | 1.6E−01 | 0.02 | chr6 | 109761938 | Island | SMPD2 | 5′UTR |
cg04838987 | − 1.76 | 3.98E−06 | 1.6E−01 | *− 0.18 | chr20 | 33734406 | N_Shore | EDEM2 | Body |
cg11241206 | − 2.82 | 4.44E−06 | 1.6E−01 | *− 0.35 | chr11 | 27723128 | S_Shore | BDNF | TSS1500; 5′UTR |
cg03611060 | 2.51 | 5.00E−06 | 1.6E−01 | *− 0.14 | chr1 | 59281067 | Island |  |  |
cg26347887 | − 2.87 | 5.16E−06 | 1.6E−01 | *− 0.28 | chr2 | 88927196 | Island | EIF2AK3 | TSS200 |