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Fig. 5 | Clinical Epigenetics

Fig. 5

From: Whole-genome methylation profiling of the retinal pigment epithelium of individuals with age-related macular degeneration reveals differential methylation of the SKI, GTF2H4, and TNXB genes

Fig. 5

Global methylation analysis of LINE-1 using bisulfite pyrosequencing of AMD RPE cells compared to normals. Mean methylation of LINE-1 compared to normals using bisulfite pyrosequencing. a LINE-1 analysis did not identify significant differences between AMD donor RPE cells (n = 29) and normal donor RPE cells (n = 23) (p = 0.8788). Sex-stratified analyses revealed no significant methylation differences in AMD male (n = 17) compared to normal male (n = 18) (p = 0.7730) (b) or AMD female (n = 12) compared to normal female human RPE cells (n = 5) (p = 0.8361) (c). All statistical analysis was performed using the Mann-Whitney U test

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