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Fig. 1 | Clinical Epigenetics

Fig. 1

From: Whole-genome methylation profiling of the retinal pigment epithelium of individuals with age-related macular degeneration reveals differential methylation of the SKI, GTF2H4, and TNXB genes

Fig. 1

Differentially methylated region identified within tenascin X (TNXB). Upper panel: schematic representation of differentially methylated region (DMR) identified in the Illumina 450k BeadChip array spanning 424 bp containing 15 CpG probes within exon 3 of TNXB. Lower panel: univariate analyses of β values of seven CpG probes within the differentially methylated region. ag Significant decrease in methylation is shown at seven CpG probes within the DMR in TNXB (cg01337207, p = 0.0204; cg26266427, p = 0.0361; cg10365886, p = 0.0248; cg07524919, p = 0.0065; cg00872984, p = 0.0088; cg27387193, p = 0.0191; cg17662683, p = 0.0233) (*p ≤ 0.05, **p ≤ 0.01). Mann-Whitney U test was used for statistical analyses between all groups tested

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