Table 1 Results from the discovery and secondary epigenome-wide association analyses of serum cotinine levels in current smokers

cg25189904

GNG12

5.6E−07

9.0E−03

1.8E−06

3.1E−02

cg21033965

CLEC20A

4.0E−06

3.7E−02

**

cg26687670

OPN3

6.5E−06

4.4E−02

**

cg27241845

ALPP

3.3E−07

6.2E−03

8.8E−07

1.7E−02

cg03329539

ALPPL2

2.7E−08

6.6E−04

1.3E−07

3.0E−03

cg06644428

ALPPL2

5.5E−06

4.3E−02

**

cg05951221

ALPPL2

1.9E−15

2.0E−10

1.4E−13

1.5E−08

cg21566642

ALPPL2

1.1E−14

8.8E−10

4.2E−13

3.4E−08

cg01940273

ALPPL2

9.8E−14

6.3E−09

3.4E−12

2.2E−07

cg13193840

ALPPL2

3.6E−06

3.4E−02

2.5E−06

3.3E−02

cg02306995

SEMA5B

4.4E−06

4.8E−02

cg04776445

MSX1

4.3E−06

4.8E−02

cg13740236

LSM6

2.9E−08

6.7E−04

1.0E−08

3.0E−04

cg11902777

AHRR

1.1E−09

3.2E−05

2.1E−08

5.6E−04

cg01899089

AHRR

6.1E−06

4.4E−02

cg05575921

AHRR

3.3E−18

1.1E−12

4.4E−16

1.1E−10

cg26703534

AHRR

5.8E−10

1.9E−05

6.2E−09

2.0E−04

cg14817490

AHRR

2.4E−06

2.9E−02

cg25648203

AHRR

4.3E−09

1.1E−04

1.1E−07

2.8E−03

cg21161138

AHRR

1.8E−17

2.9E−12

6.6E−16

1.1E−10

cg24090911

AHRR

4.3E−07

7.4E−03

2.5E−06

3.3E−02

cg10961758

EDIL3

2.5E−06

3.3E−02

cg16179182

VTRNA1–1

5.7E−06

4.3E−02

cg14580211

SMIM3

1.7E−06

2.2E−02

cg06126421

IER3

1.1E−10

4.3E−06

6.9E−10

2.8E−05

cg14753356

IER3

3.1E−06

3.4E−02

cg22856972

TBPL1

3.0E−06

3.4E−02

9.1E−07

1.7E−02

cg05469934

PDGFA

3.6E−06

3.4E−02

cg09022230

TNRC18

4.1E−08

8.8E−04

2.4E−06

3.3E−02

cg21322436

CNTNAP2

5.6E−06

4.3E−02

cg25949550

CNTNAP2

1.4E−06

1.9E−02

cg09267815

YTHDF3

7.2E−07

1.1E−02

cg22288066

NOV

6.8E−06

4.4E−02

cg24838345

MTSS1

2.6E−07

5.3E−03

2.3E−06

3.3E−02

[2,3,4,5,6, 8, 9]

cg25305703

CASC8

1.7E−06

2.2E−02

[2,3,4,5,6,7]

cg01692968

SLC44A1

3.3E−06

3.4E−02

2.7E−06

3.3E−02

cg14120703

NOTCH1

4.3E−06

3.8E−02

4.3E−06

4.8E−02

cg05992400

CYP2C18

4.9E−06

4.1E−02

cg16421726

ZRANB1

2.7E−06

3.1E−02

cg05335388

ABTB2

1.6E−06

2.9E−02

cg19254163

PTGDR2

6.4E−06

4.4E−02

cg21611682

LRP5

1.2E−12

6.7E−08

8.2E−11

3.8E−06

cg14624207

LRP5

2.6E−10

9.2E−06

1.4E−09

5.1E−05

cg10788371

LRRC32

1.3E−06

1.8E−02

8.6E−07

1.7E−02

cg11491407

CACNA2D4

5.7E−06

4.3E−02

cg18443392

LRP1

4.2E−06

3.8E−02

cg04524475

RNY1P5

6.2E−06

4.4E−02

cg26589665

THSD4

3.8E−07

6.9E−03

2.1E−06

3.3E−02

cg05361530

GNG13

4.8E−06

4.1E−02

cg07991586

ADCY7

6.6E−06

4.4E−02

cg05460226

PIK3R5

3.4E−06

3.4E−02

cg05396243

TMEM220-AS1

1.0E−06

1.5E−02

cg07658936

ARHGAP44

6.8E−06

4.4E−02

cg03636183

F2RL3

1.9E−11

8.7E−07

2.8E−11

1.5E−06

cg12817959

SSTR3

4.3E−06

4.8E−02