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Fig. 6 | Clinical Epigenetics

Fig. 6

From: Elevated H3K27me3 levels sensitize osteosarcoma to cisplatin

Fig. 6

Alterations in H3K27me3 regulate apoptosis- and stemness-related genes involved in OS chemosensitivity to cisplatin. a Heatmap of differential gene expression profiles based on RNAseq. b Functional protein association network analysis of differential gene expression profiles based on RNAseq. c Venn diagram showing the number of differentially expressed genes in and shared between the indicated groups. d RT-qPCR analysis of PRKCA, BMF, BAX, MCL1, BCL2, MYC, KLF4, SOX9, and CD117 expression. #P < 0.05, ##P < 0.01 compared with the Ctrl group.*P < 0.05, **P < 0.01 compared with the Cis group

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