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Table 2 Meta-analysis of the associations of DNA methylation at the top 10 CpG sites associated with 8-isoprostane concentrations in the two validation sets

From: The associations of DNA methylation alterations in oxidative stress-related genes with cancer incidence and mortality outcomes: a population-based cohort study

Identified CpG sites Gene name Pathways ß-coefficient SE P value FDR
cg25365794 ALOXE3 Prostaglandin 2 biosynthesis and metabolism − 4.540 1.338 0.001 0.010
cg01009697 NTRK2 PI3K/Akt and MAPK signaling pathways − 2.266 0.780 0.004 0.020
cg08862778 MTOR Various pathways, such as PI3K/Akt − 3.326 1.270 0.009 0.030
cg27095527 PPARG Nuclear receptors in lipid metabolism and toxicity − 0.694 0.695 0.318 0.694
cg05784862 KSR1 RET signaling and MAPK signaling pathways − 0.224 0.295 0.447 0.694
cg19623877 MYB Response to elevated platelet cytosolic Ca2+ 0.427 0.604 0.480 0.694
cg06671842 PTPN5 PAK and MAPK signaling pathways − 0.307 0.440 0.486 0.694
cg19192120 SSH3 Regulation of actin cytoskeleton and cytoskeletal signaling pathways − 0.094 0.321 0.769 0.898
cg02168857 EPHA7 EPHA forward signaling pathway − 0.117 0.480 0.808 0.898
cg15093079 EPHA6 EPHA forward signaling pathway 0.025 0.659 0.969 0.969
  1. Abbreviations: Akt protein kinase B, ALOXE3 arachidonate lipoxygenase 3, EPHA6 EPH receptor A6, EPHA7 EPH receptor A7, FDR false discovery rate, KSR1 Kinase suppressor of Ras 1, MAPK mitogen-activated protein kinase, MTOR mechanistic target of rapamycin kinase, MYB MYB proto-oncogene, transcription factor, NTRK2 neurotrophic receptor tyrosine kinase 2, PI3K phosphoinositide 3-kinase, PPARG peroxisome proliferator activated receptor gamma, PTPN5 protein tyrosine phosphatase, non-receptor type 5, SE standard error, SSH3 slingshot protein phosphatase 3