The associations of DNA methylation alterations in oxidative stress-related genes with cancer incidence and mortality outcomes: a population-based cohort study

Table 2 Meta-analysis of the associations of DNA methylation at the top 10 CpG sites associated with 8-isoprostane concentrations in the two validation sets

Identified CpG sites	Gene name	Pathways	ß-coefficient	SE	P value	FDR
cg25365794	ALOXE3	Prostaglandin 2 biosynthesis and metabolism	− 4.540	1.338	0.001	0.010
cg01009697	NTRK2	PI3K/Akt and MAPK signaling pathways	− 2.266	0.780	0.004	0.020
cg08862778	MTOR	Various pathways, such as PI3K/Akt	− 3.326	1.270	0.009	0.030
cg27095527	PPARG	Nuclear receptors in lipid metabolism and toxicity	− 0.694	0.695	0.318	0.694
cg05784862	KSR1	RET signaling and MAPK signaling pathways	− 0.224	0.295	0.447	0.694
cg19623877	MYB	Response to elevated platelet cytosolic Ca²⁺	0.427	0.604	0.480	0.694
cg06671842	PTPN5	PAK and MAPK signaling pathways	− 0.307	0.440	0.486	0.694
cg19192120	SSH3	Regulation of actin cytoskeleton and cytoskeletal signaling pathways	− 0.094	0.321	0.769	0.898
cg02168857	EPHA7	EPHA forward signaling pathway	− 0.117	0.480	0.808	0.898
cg15093079	EPHA6	EPHA forward signaling pathway	0.025	0.659	0.969	0.969

Abbreviations: Akt protein kinase B, ALOXE3 arachidonate lipoxygenase 3, EPHA6 EPH receptor A6, EPHA7 EPH receptor A7, FDR false discovery rate, KSR1 Kinase suppressor of Ras 1, MAPK mitogen-activated protein kinase, MTOR mechanistic target of rapamycin kinase, MYB MYB proto-oncogene, transcription factor, NTRK2 neurotrophic receptor tyrosine kinase 2, PI3K phosphoinositide 3-kinase, PPARG peroxisome proliferator activated receptor gamma, PTPN5 protein tyrosine phosphatase, non-receptor type 5, SE standard error, SSH3 slingshot protein phosphatase 3

ISSN: 1868-7083