Table 2 Alleles and genotypes distribution of MTHFR and MTRR
From: TRIM4 is associated with neural tube defects based on genome-wide DNA methylation analysis
| Â | Genotype/allele | Controls, n (%) | NTDs, n (%) | p | OR (CI 95%) |
|---|---|---|---|---|---|
Sample size (n) | Â | 14 (100) | 14 (100) | Â | Â |
MTHFR C677T | |||||
 Genotype frequency | CC | 1 (7.1) | 3 (21.4) | 0.643 |  |
CT | 8 (57.1) | 6 (42.9) | |||
TT | 5 (35.7) | 5 (35.7) | |||
 Allele frequency | C | 10 (35.7) | 12 (42.9) | 0.785 | 0.741 (0.253–2.173) |
T | 18 (64.3) | 16 (57.1) | |||
MTHFR A1298C | |||||
 Genotype frequency | AA | 9 (64.3) | 12 (85.7) | 0.385 |  |
AC | 5 (35.7) | 2 (14.3) | |||
CC | 0 (0) | 0 (0) | |||
 Allele frequency | A | 23 (82.1) | 26 (92.9) | 0.422 | 0.354 (0.063–2.002) |
C | 5 (17.9) | 2 (7.1) | |||
MTRR A66G | |||||
 Genotype frequency | AA | 5 (35.7) | 7 (50.0) | 0.214 |  |
AG | 9 (64.3) | 5 (35.7) | |||
GG | 0 (0) | 2 (14.3) | |||
 Allele frequency | A | 19 (67.9) | 19 (67.9) | 1.000 | 1.000 (0.326–3.070) |
G | 9 (32.1) | 9 (32.1) | |||