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Table 2 Alleles and genotypes distribution of MTHFR and MTRR

From: TRIM4 is associated with neural tube defects based on genome-wide DNA methylation analysis

  Genotype/allele Controls, n (%) NTDs, n (%) p OR (CI 95%)
Sample size (n)   14 (100) 14 (100)   
MTHFR C677T
 Genotype frequency CC 1 (7.1) 3 (21.4) 0.643  
CT 8 (57.1) 6 (42.9)
TT 5 (35.7) 5 (35.7)
 Allele frequency C 10 (35.7) 12 (42.9) 0.785 0.741 (0.253–2.173)
T 18 (64.3) 16 (57.1)
MTHFR A1298C
 Genotype frequency AA 9 (64.3) 12 (85.7) 0.385  
AC 5 (35.7) 2 (14.3)
CC 0 (0) 0 (0)
 Allele frequency A 23 (82.1) 26 (92.9) 0.422 0.354 (0.063–2.002)
C 5 (17.9) 2 (7.1)
MTRR A66G
 Genotype frequency AA 5 (35.7) 7 (50.0) 0.214  
AG 9 (64.3) 5 (35.7)
GG 0 (0) 2 (14.3)
 Allele frequency A 19 (67.9) 19 (67.9) 1.000 1.000 (0.326–3.070)
G 9 (32.1) 9 (32.1)