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Fig. 7 | Clinical Epigenetics

Fig. 7

From: Demethylation by low-dose 5-aza-2′-deoxycytidine impairs 3D melanoma invasion partially through miR-199a-3p expression revealing the role of this miR in melanoma

Fig. 7

Patient sample analysis and schematic representation of the role of miR-199-3p in melanoma aggressiveness. a DNA methylation level of six consecutive CpG sites in the genomic vicinity of MIR199A2 gene. TCGA SCKM data was classified according to the melanoma tissue type. b microRNA-199A2 expression according to melanoma tissue types. c DNA methylation of Mir-199A2 were analysed in formaldehyde-fixated samples from 12 PT, 15 LN and 16 DM (10 bowel and 6 liver) samples. Median methylation of all the CpG sites is represented. d Schematic representation of MIR199A promoter methylation and expression as a function of the clinical stages. Blue arrows indicate a decrease in the DNA methylation and red arrows an increase. Green arrows indicate a decrease in the miR expression and red arrows an increase

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