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Table 5 Changes in epigenetic mark immunoreactivity—human neocortex tissue array samples

From: DNA methylation and histone post-translational modification stability in post-mortem brain tissue

  Normal Subacute hypoxic changes
Epigenetic modification 3 days post-mortem 4 days post-mortem 5 days post-mortem 31–43 h post-mortem
5mC No change No change No change Cytoplasm leakage
5hmC No change No change No change Few (−) small nuclei
5fC No change No change Moderate decrease; glial and neuronal No change
5caC No change No change Moderate decrease; neuronal Few small nuclei are (−)
H3K4me3 Minor cytoplasmic labeling Minor decrease, neuronal Minor decrease, neuronal Cytoplasm leakage
H3K27me3 No change Few (−) glial cells No change No change
H3K36me3 No change Minor decrease; glial and neuronal Minor decrease; glial and neuronal Minor decrease; neuronal
H3panAc No change Minor decrease; glial and neuronal Minor decrease; glial and neuronal Minor decrease; glial and neuronal
H3K9ac No change Minor decrease; glial Minor decrease; glial and neuronal Few small nuclei are (−)
H3K14ac Minor decrease; glial and neuronal Minor decrease; glial Moderate decrease; neuronal; few (−) neurons Minor decrease; glial, Moderate decrease; neuronal; few (−) neurons Minor to moderate decrease; glial and neuronal; few (−) neurons
H3K27ac Minor decrease; glial Few small nuclei are (−) Few small nuclei are (−) Few small nuclei are (−)
H4K5ac No change Moderate decrease; glial and neuronal Few small nuclei are (−) No change
H4K12ac No change No change No change No change
  1. Note: There were no obvious differences between the specimens obtained surgically and fixed < 1 h after devitalization and the autopsy samples that were fixed ≤ 2 days after death, unless there were also changes due to hypoxic-ischemic brain damage