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Fig. 9 | Clinical Epigenetics

Fig. 9

From: DNA methylation and histone post-translational modification stability in post-mortem brain tissue

Fig. 9

Bar graphs showing the quantitative analysis (mean ± 95% confidence intervals; maximum 100%) for nuclear immunostaining of selected epigenetic marks in neonatal pig neocortex. ANOVA F statistic and p values are also shown. Data are shown separately for large round nuclei (neurons) and smaller irregular nuclei (glial cells and/or interneurons). 5mC, H3K27me3, H3K27ac, and H4K12ac were stable at all post-mortem times to 72 h in both populations. H3K9ac declined in neurons, but not glial cells. H3K14ac and H4K16ac declined in glial cells, but only rare neurons were labeled in the control state (0 h). H4K5ac was lost in both neurons and glial cells. p values for all statistical comparisons shown at bottom and were subjected to the Dunnett’s post hoc test (p < 0.05)

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