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Fig. 2 | Clinical Epigenetics

Fig. 2

From: Preferential MGMT methylation could predispose a subset of KIT/PDGFRA-WT GISTs, including SDH-deficient ones, to respond to alkylating agents

Fig. 2

MGMT protein expression assessed by IHC in six examples of GIST. At MGMT IHC, MGMT-unmethylated GISTs 43 (a), 26 (b), and 27 (c) featured nuclear staining in the majority of cells (score 3), unlike MGMT-methylated GISTs 32 (d), 31 (e), and 44 (f) (score 1). Endothelial and lymphoid cells (the periphery of a lymphoid aggregate is evident in e, top left) act as internal positive controls. (Scale bars: 20 μm)

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Clinical Epigenetics

ISSN: 1868-7083

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