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Table 3 Differentially methylated regions

From: Significantly altered peripheral blood cell DNA methylation profile as a result of immediate effect of metformin use in healthy individuals

Contrast

Gene

FDR

Number of probes

Chr

Start (bp)a

End (bp)a

Transcription factorsb

M10h vs M0

EPHB1

1.60E−11

3

3

134,515,421

134,516,302

–

CDCA7L

3.83E−07

5

7

21,985,276

21,985,628

Nr1h3

CLVS2

8.21E−07

10

6

123,317,123

123,317,875

Nrsf

BACE2, MIR3197

1.38E−06

3

21

42,539,960

42,540,409

CTCF

EXPH5

5.76E−06

6

11

108,464,101

108,464,498

Cmyc; Egr1; FOXA1; MYC; Max; SP1;

KCNE4

1.50E−05

3

2

223,916,686

223,916,861

USF1

TTC38

1.50E−05

4

22

46,685,471

46,685,728

NA

TTC39A

1.51E−05

5

1

51,810,626

51,811,022

–

NA

2.17E−05

3

4

153,897,215

153,897,453

NA

NA

2.33E−05

3

10

132,891,318

132,891,371

NA

M7d vs M0

SFRP2

1.18E−11

28

4

132,891,371

154,711,183

CTCF; Egr1

GPR19

4.59E−10

11

12

12,848,515

12,849,588

E2F4; ZBTB33;

TMEM216

3.46E−07

7

11

61,159,601

61,159,837

CTCF; Egr1; Gabp; Yy1

  1. aPhysical position (basepair, hg37)
  2. bData from Ensembl 91 regulation resources [98], hg38