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Table 1 Demographics and clinical variables in the study population

From: Machine learning selected smoking-associated DNA methylation signatures that predict HIV prognosis and mortality

  Cohort 1 (Illumina 450K) Cohort 2 (Illumina Epic)
Smokers (N = 361) Non-smokers (N = 247) p Smokers (N = 309) Non-smokers (N = 220) p
HIV-positive (%) 100 100 N/A 100 100 N/A
Age 49.2 ± 6.74 49.7 ± 8.70 0.44 48.0 ± 6.55 48.3 ± 9.20 0.62
Sex (male, %) 100 100 N/A 100 100 N/A
Race (AA, %) 87.5 83.4 0.01 79 82.7 0.32
AUDIT-C 4.00 ± 3.32 3.72 ± − 3.48 0.31 3.67 ± 3.05 2.99 ± 2.89 0.01
ART (%) 76.5 76.1 0.87 69.6 83.2 0.0004
WBC 5.35 ± 2.09 5.34 ± 1.81 0.95 5.27 ± 1.96 5.27 ± 1.55 0.99
CD4 408 ± 290 457 ± 272 0.04 415 ± 200 493 ± 280 0.002
VL (log10) 2.75 ± 1.24 2.52 ± 1.15 0.03 2.82 ± 1.26 2.55 ± 1.20 0.02
CD8* 0.18 ± 0.08 0.17 ± 0.08 0.40 0.16 ± 0.08 0.17 ± 0.08 0.38
CD4* 0.05 ± 0.05 0.05 ± 0.05 0.33 0.07 ± 0.05 0.08 ± 0.06 0.19
Nature killer cells* 0.06 ± 0.05 0.09 ± 0.07 < 0.0005 0.08 ± 0.05 0.09 ± 0.06 < 0.005
B cell* 0.09 ± 0.05 0.08 ± 0.05 0.47 0.11 ± 0.05 0.11 ± 0.04 0.44
Monocytes* 0.12 ± 0.04 0.12 ± 0.04 0.83 0.11 ± 0.04 0.10 ± 0.04 0.002
Granulocytes* 0.53 ± 0.13 0.51 ± 0.12 0.07 0.51 ± 0.11 0.49 ± 0.11 0.02
  1. AA African-American, AUDIT Alcohol Use Disorder Identification Test, ART antiretroviral therapy, VL viral load
  2. *Methylation-based cell type deconvolution by Housman et al. algorithm