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Table 1 Demographics and clinical variables in the study population

From: Machine learning selected smoking-associated DNA methylation signatures that predict HIV prognosis and mortality

 

Cohort 1 (Illumina 450K)

Cohort 2 (Illumina Epic)

Smokers (N = 361)

Non-smokers (N = 247)

p

Smokers (N = 309)

Non-smokers (N = 220)

p

HIV-positive (%)

100

100

N/A

100

100

N/A

Age

49.2 ± 6.74

49.7 ± 8.70

0.44

48.0 ± 6.55

48.3 ± 9.20

0.62

Sex (male, %)

100

100

N/A

100

100

N/A

Race (AA, %)

87.5

83.4

0.01

79

82.7

0.32

AUDIT-C

4.00 ± 3.32

3.72 ± − 3.48

0.31

3.67 ± 3.05

2.99 ± 2.89

0.01

ART (%)

76.5

76.1

0.87

69.6

83.2

0.0004

WBC

5.35 ± 2.09

5.34 ± 1.81

0.95

5.27 ± 1.96

5.27 ± 1.55

0.99

CD4

408 ± 290

457 ± 272

0.04

415 ± 200

493 ± 280

0.002

VL (log10)

2.75 ± 1.24

2.52 ± 1.15

0.03

2.82 ± 1.26

2.55 ± 1.20

0.02

CD8*

0.18 ± 0.08

0.17 ± 0.08

0.40

0.16 ± 0.08

0.17 ± 0.08

0.38

CD4*

0.05 ± 0.05

0.05 ± 0.05

0.33

0.07 ± 0.05

0.08 ± 0.06

0.19

Nature killer cells*

0.06 ± 0.05

0.09 ± 0.07

< 0.0005

0.08 ± 0.05

0.09 ± 0.06

< 0.005

B cell*

0.09 ± 0.05

0.08 ± 0.05

0.47

0.11 ± 0.05

0.11 ± 0.04

0.44

Monocytes*

0.12 ± 0.04

0.12 ± 0.04

0.83

0.11 ± 0.04

0.10 ± 0.04

0.002

Granulocytes*

0.53 ± 0.13

0.51 ± 0.12

0.07

0.51 ± 0.11

0.49 ± 0.11

0.02

  1. AA African-American, AUDIT Alcohol Use Disorder Identification Test, ART antiretroviral therapy, VL viral load
  2. *Methylation-based cell type deconvolution by Housman et al. algorithm