Table 3 Changes in mtDNA methylation of the GBM genotype resulting from different nuclear genomes
From: The degree of mitochondrial DNA methylation in tumor models of glioblastoma and osteosarcoma
Location of C | Strand | Annotation | 143BGBM Early vs. GBM cell | 143BGBM Late vs. GBM cell | ||
|---|---|---|---|---|---|---|
P | Difference | P | Difference | |||
170 | + | Non-coding | * | 7.49% | ||
1597 | + | RNR1 | * | 4.96% | ||
2719 | − | RNR2 | * | 34.26% | ** | 27.12% |
2810 | − | RNR2 | * | − 30.90% | ||
3022 | − | RNR2 | * | − 7.12% | ||
3061 | − | RNR2 | * | 8.50% | ||
3094 | − | RNR2 | ** | 5.58% | ** | 4.74% |
3945 | − | ND1 | * | 6.56% | ||
3950 | + | ND1 | * | 6.81% | * | 9.48% |
3965 | + | ND1 | * | 4.92% | * | 3.03% |
4664 | − | ND2 | * | 6.06% | * | 4.63% |
5110 | + | ND2 | * | 5.61% | * | 6.75% |
6241 | + | CO1 | * | 9.05% | ||
6850 | + | CO1 | * | − 12.72% | * | − 8.53% |
7218 | − | CO1 | * | 5.96% | * | 4.56% |
7336 | − | CO1 | * | 5.02% | * | 3.97% |
8544 | − | ATP8; ATP6 | ** | 8.51% | * | 7.57% |
9008 | + | ATP6 | * | 6.14% | ||
10012 | + | TG | * | 8.09% | ||
10169 | − | ND3 | * | 12.33% | ||
10174 | + | ND3 | * | − 12.72% | ||
10426 | − | TR | ** | 7.18% | * | 8.24% |
10584 | + | ND4L | ** | 4.66% | * | 5.54% |
11765 | − | ND4 | * | − 5.74% | ** | − 6.44% |
13120 | – | ND5 | *** | − 8.22% | *** | − 7.38% |
13938 | + | ND5 | * | − 34.96% | ||
14248 | − | ND6 | * | − 11.83% | * | − 12.43% |
15043 | + | CYTB | ** | − 31.92% | * | − 31.28% |