Fig. 5
From: The degree of mitochondrial DNA methylation in tumor models of glioblastoma and osteosarcoma
Levels of DNA methylation at different regions of the mitochondrial genome in GBM100, GBM50, GBM3, and GBM0.2 tumors. DNA methylation levels (5mC/5hmC) within regions of the mitochondrial genome were determined on purified mtDNA samples using MeDIP. Statistical significance was determined between the GBM100, GBM50, GBM3, and GBM0.2 tumors by one-way ANOVA. Bars represent the mean of the relative quantification levels (mean ± SEM; n = 3). *, **, *** indicate p values of < 0.05, 0.01, 0.001, respectively