Fig. 4
From: The degree of mitochondrial DNA methylation in tumor models of glioblastoma and osteosarcoma
Levels of DNA methylation of the same mtDNA genotype under a different nuclear genome. a Levels of DNA methylation for GBM mtDNA in association with the GBM (GBM100) and 143B (143BGBM) nuclear genomes. b Levels of DNA methylation of hNSC mtDNA under the hNSC and 143B (143BNSC) nuclear genomes. DNA methylation levels (5mC/5hmC) were determined on purified mtDNA samples using MeDIP. Statistical significance was determined between each type by multiple t tests. Bars represent the mean of the relative quantification levels (mean ± SEM; n = 3). *, ** indicate p values of < 0.05, 0.01, respectively