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Table 4 Integration of epigenetic fingerprint loci with gene expression

From: Analysis of repeated leukocyte DNA methylation assessments reveals persistent epigenetic alterations after an incident myocardial infarction

Chrom

GEX Probe

CpG

BP

Annotated gene

Beta

SE

P

Probe gene

1

ILMN_1725510

cg10073091*

55.35

DHCR24

− 1.76

0.51

0.0006

DHCR24

1

ILMN_1673544

cg10073091*

55.35

DHCR24

2.37

0.73

0.0012

TCEANC2

1

ILMN_1681340

cg10073091

55.35

DHCR24

− 4.29

1.54

0.0055

HSPB11

19

ILMN_1654571

cg23541257

18.10

KCNN1

− 1.52

0.63

0.02

FCHO1

19

ILMN_1742917

cg23541257

18.10

KCNN1

1.00

0.45

0.03

NXNL1

14

ILMN_1758038

cg23074119

78.17

ALKBH1

− 25.80

11.89

0.03

ALKBH1

1

ILMN_1671568

cg21609024

53.80

LRP8

2.02

0.94

0.03

ECHDC2

19

ILMN_1797005

cg23541257

18.10

KCNN1

− 1.36

0.64

0.03

PGLS

6

ILMN_2121272

cg00699486

166.14

 

− 0.42

0.21

0.04

PDE10A

  1. Beta effect estimate for gene expression—methylation association, BP chromosomal location of the CpG, P unadjusted P value, SE standard error
  2. Of the nine epigenetic fingerprint loci, five were at least nominally associated (P < 0.05) with cis-gene expression (1 Mb window). Two, marked with an asterisk (*), were associated after adjusting for the number cis-genes, i.e., genes within 1 Mb. Annotated gene refers to the proximity-based annotation of the methylation probe (CpG) to a gene by Illumina. Probe gene refers to the gene associated with the gene expression (GEX) probe