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Table 4 Integration of epigenetic fingerprint loci with gene expression

From: Analysis of repeated leukocyte DNA methylation assessments reveals persistent epigenetic alterations after an incident myocardial infarction

Chrom GEX Probe CpG BP Annotated gene Beta SE P Probe gene
1 ILMN_1725510 cg10073091* 55.35 DHCR24 − 1.76 0.51 0.0006 DHCR24
1 ILMN_1673544 cg10073091* 55.35 DHCR24 2.37 0.73 0.0012 TCEANC2
1 ILMN_1681340 cg10073091 55.35 DHCR24 − 4.29 1.54 0.0055 HSPB11
19 ILMN_1654571 cg23541257 18.10 KCNN1 − 1.52 0.63 0.02 FCHO1
19 ILMN_1742917 cg23541257 18.10 KCNN1 1.00 0.45 0.03 NXNL1
14 ILMN_1758038 cg23074119 78.17 ALKBH1 − 25.80 11.89 0.03 ALKBH1
1 ILMN_1671568 cg21609024 53.80 LRP8 2.02 0.94 0.03 ECHDC2
19 ILMN_1797005 cg23541257 18.10 KCNN1 − 1.36 0.64 0.03 PGLS
6 ILMN_2121272 cg00699486 166.14   − 0.42 0.21 0.04 PDE10A
  1. Beta effect estimate for gene expression—methylation association, BP chromosomal location of the CpG, P unadjusted P value, SE standard error
  2. Of the nine epigenetic fingerprint loci, five were at least nominally associated (P < 0.05) with cis-gene expression (1 Mb window). Two, marked with an asterisk (*), were associated after adjusting for the number cis-genes, i.e., genes within 1 Mb. Annotated gene refers to the proximity-based annotation of the methylation probe (CpG) to a gene by Illumina. Probe gene refers to the gene associated with the gene expression (GEX) probe