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Table 1 Clinical covariates for KORA, NAS, and InCHIANTI

From: Analysis of repeated leukocyte DNA methylation assessments reveals persistent epigenetic alterations after an incident myocardial infarction

a. Clinical covariates at baseline and follow-up exams
  KORA NAS InCHIANTI
  Baseline Follow-up Baseline Follow-up Baseline Follow-up
N 1103 1103 344 344 443 443
N MI 13 14 50
Time to MI—years; mean (SD) 4.08 (2.2) 2.76 (1.3) 6.47 (2.9)
FU time—years; mean (SD) 7.10 (0.22) 8.52 (3.2) 9.12 (0.21)
Age—years; mean (SD) 54.5 (8.87) 61.5 (8.9) 70.9 (6.6) 74.5 (6.6) 61.7 (16.2) 70.8 (16.2)
Males—N (%) 558 (50.6%) 558 (50.6%) 100% 100% 206 (46.5%) 206 (46.5%)
BMI—kg/m2; mean (SD) 27.7 (4.5) 28.1 (4.8) 28.1 (4.1) 27.7 (4.1) 27.0 (3.9) 27.0 (4.3)
Current smokers—N (%) 212 (19.2%) 161 (14.6%) 17 (4.94%) 16 (4.65%) 89 (20.1%) 45 (10.2%)
Former smokers—N (%) 417 (37.8%) 469 (42.5%) 220 (64.0%) 222 (64.5%) 105 (23.7%) 151 (34.1%)
LDL-C—mg/dL; mean (SD) 144 (40.1) 140 (35.8) 135 (35.9) 124 (31.8)
HDL-C—mg/dL; mean (SD) 57.5 (16.9) 56.2 (14.8) 51.3 (14.1) 50.6 (13.5) 56.1 (14.2) 56.5 (15.2)
Hypertension—N (%) 484 (44.2%) 522 (47.4%) 209 (60.8%) 232 (67.4%) 221 (49.9%) 247 (55.8%)
Type 2 diabetes—N (%) 39 (3.54%) 105 (9.53%) 36 (10.5%) 48 (14.0%) 38 (8.6%) 49 (11.1%)
b. Clinical covariates at baseline for individuals who did not develop an MI (controls) vs those who did (cases)
  KORA NAS InCHIANTI
  Controls Cases Controls Cases Controls Cases
N 1090 13 330 14 393 50
Age—years; mean (SD) 54.4 (8.9) 58.9 (7.2) 70.9 (6.5) 69.3 (8.4) 60.9 (16.7) 67.8 (9.4)
Males—N (%) 548 (50.3%) 10 (76.9%) 100% 100% 181 (46.1%) 25 (50.0%)
BMI—kg/m2; mean (SD) 27.7 (4.4) 31 (7.1) 28.0 (4.1) 29.0 (4.0) 26.9 (3.9) 27.3 (3.46)
Current smokers—N (%) 208 (19.1%) 4 (30.8%) 16 (4.84%) 1 (7.14%) 80 (20.4%) 9 (18.0%)
Former smokers—N (%) 412 (37.8%) 5 (38.5%) 210 (63.6%) 10 (71.4%) 88 (22.4%) 17 (34.0%)
LDL—mg/dL; mean (SD) 144 (40.2) 144 (36.7) 134 (35.9) 144 (34.6)
HDL—mg/dL; mean (SD) 57.7 (16.8) 42 (11.7) 51.7 (14.1) 41.7 (8.5) 56.0 (14.3) 57.6 (13.2)
Hypertension—N (%) 476 (44%) 8 (61.5%) 201 (60.9%) 8 (57.1%) 187 (47.6%) 34 (68.0%)
Type 2 diabetes—N (%) 37 (3.4%) 2 (15.4%) 32 (9.70%) 4 (28.6%) 31 (7.9%) 7 (14.0%)
c. Clinical covariates at follow-up for individuals who did not develop an MI (controls) vs those who did (cases)
  KORA NAS InCHIANTI
  Controls Cases Controls Cases Controls Cases
N 1090 13 330 14 393 50
Time to MI—years; mean (SD) 4.08 (2.2) 2.76 (1.3) 6.47 (2.9)
FU time—years; mean (SD) 7.1 (0.22) 7.2 (0.38) 8.8 (2.97) 2.8 (1.3) 9.1 (0.21) 9.1 (0.21)
Age—years; mean (SD) 61.4 (8.9) 65.9 (7.2) 74.5 (6.5) 73.3 (8.2) 70.0 (16.7) 76.9 (9.5)
Males—N (%) 548 (50.3%) 10 (76.9%) 100% 100% 181 (46.1%) 25 (50.0%)
BMI—kg/m2; mean (SD) 28.1 (4.71) 32.6 (7.24) 27.7 (4.1) 28.3 (4.2) 27.0 (4.35) 27.0 (3.72)
Current smokers—N (%) 159 (14.6%) 2 (15.4%) 15 (4.6%) 1 (7.1%) 42 (10.7%) 3 (6.0%)
Former smokers—N (%) 462 (42.4%) 7 (53.8%) 212 (64.2%) 10 (71.4%) 128 (32.6%) 23 (46.0%)
LDL-C—mg/dL; mean (SD) 140 (35.8) 111 (16.8) 123 (31.9) 127 (31.4)
HDL-C—mg/dL; mean (SD) 56.4 (14.8) 41.5 (10.2) 51.1 (13.6) 40.3 (6.0) 56.4 (15.3) 57.3 (14.6)
Hypertension—N (%) 513 (47.2%) 9 (69.2%) 219 (66.3%) 13 (92.9%) 216 (55.0%) 31 (62.0%)
Type 2 diabetes—N (%) 98 (9.0%) 7 (53.8%) 43 (13.0%) 5 (35.7%) 44 (11.2) 5 (10.0%)
  1. Summary given as mean (SD) for continuous variables: time to myocardial infarction (time to MI), follow-up time (FU time), age, body mass index (BMI), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C). Summary given as the number and percentage responding positively for binary variables: males, current smokers, former smokers, hypertension, and type 2 diabetes