Noncoding RNAs in multiple sclerosis

Clinical Epigenetics

Table 3 Published values of Sn, Sp, and AUC for biomarker candidates for MS

NcRNA subtype within	NcRNA name	Sn	Sp	AUC	Ref
MicroRNAs
Blood cells	hsa-miR-145	90.0%	89.5%	0.96	[44]
Serum/plasma	miR-223	ND	ND	0.80	[48]
	miR-15b	ND	ND	0.75	[48]
	miR-24	ND	ND	0.686	[47]
	miR-137	ND	ND	0.741	[47]
Exosome	miR-15b-5p	ND	ND	0.76	[53]
	miR-23a-3p	ND	ND	0.80	[53]
	miR-223-3p	ND	ND	0.77	[53]
	miR-374a-5p	ND	ND	0.78	[53]
	miR-30b-5p	ND	ND	0.82	[53]
	miR-433-3p	ND	ND	0.93	[53]
	miR-485-5p	ND	ND	0.87	[53]
	miR-342-3p	ND	ND	0.81	[53]
	miR-432-5p	ND	ND	0.86	[53]
CSF	miR-181c	ND	ND	0.73	[54]
	miR-922	ND	ND	0.74	[54]
	miR-633	ND	ND	0.82	[54]
	miR-150	89%	50%	0.744	[56]
CircRNAs
PBMCs	circ_0005402	94.4%	75.0%	0.899	[94]
PBMCs	circ_0035560	55%	88.9%	0.706	[94]

Sn sensibility, Sp specificity, AUC area under the curve, PBMCs peripheral blood mononuclear cells, ND not determined

ISSN: 1868-7083