Source of miRNA | Research model | Change | Target | Function | Ref |
---|---|---|---|---|---|
PBMC | |||||
 hsa-miR-18b, hsa-miR-599, hsa-miR-96 | Human | ↑ | ND | ND | [42] |
 miR-590 | Human | ↑ | Tob1 | Promote Th17 differentiation | [63] |
 miR-448 | Human | ↑ | PTPN2 | Promote Th17 differentiation | [64] |
 miR-21, miR-146a, miR-146b | Human | ↑ | ND | ND | [95] |
 miR-140-5p | Human | ↓ | STAT1 | Inhibit Th1 differentiation | [69] |
CD4+ T cell | |||||
 miR-326 | C57BL/6 mice, human | ↑ | Ets-1 | Promote Th17 differentiation | [43] |
 miR-155 | C57BL/6 mice, human | ↑ | Est-1 and Jarid2 | Promote Th17/Th1 differentiation | |
 miRNA let-7e | C57BL/6 mice | ↑ | IL-10 | Promote Th17 differentiation | [65] |
 miR27a | Human | ↑ | ND | Inhibit negative regulators of Th17 cell differentiation? | [66] |
 miR-128, miR-27b, miR-340 | C57BL/6 mice human | ↑ | BMI1? IL-4 | Promote Th1 differentiation and inhibit Th2 differentiation | [70] |
 miR-17-5p | Human | ↑ | ND | ND | [45] |
 miR-214 | Human | ↓ | ND | ND | [66] |
 miR-15b | C57BL/6 mice human | ↓ | OGT | Inhibit Th17 differentiation | [67] |
 miR-132 | C57BL/6 mice | ↓ | ND | Suppress T cell proliferation | [68] |
B cell | |||||
 miR-320a | Human | ↓ | MMP-9 | Disrupt the blood-brain barrier and digest myelin basic protein | [71] |
 miR-132 | Human | ↑ | Sirtuin-1 | ND | [75] |
 miR-106b-25 cluster, miR-17-92 cluster | Human | ↓ | PI3K? PTEN? | ND | [74] |
Serum/plasma | |||||
 miR-326 | Human | ↑ | ND | ND | [51] |
 miR-614, miR-572, miR-648, miR-1826, miR-422a, miR-22 | Human | ↑ | ND | ND | [52] |
 miR-24 and miR-137 | Human | ↑ | ND | ND | [47] |
 miR-15b, miR-23a, miR-223 | Human | ↓ | ND | ND | [48] |
 miR-155, miR-301a | Human | ↓ | ND | ND | [51] |
 miR-1979 | Human | ↓ | ND | ND | [52] |
 has-miR-let-7a, miR-648a | Human | ↓ | ND | ND | [50] |
Exosome | |||||
 miR-15b-5p, miR-23-3p, miR-223-3p, miR-30b-5p, miR-342-3p, miR-432-5p | Human | ↑ | ND | ND | [53] |
Microglia | |||||
 miR-155 | Human | ↑ | ND | ND | [77] |
 miR-124 | C57BL/6 mice | ↓ | ND | Promote the M2 phenotype of macrophages and microglia | [76] |
Active lesions | |||||
 miR-34a, miR-155, miR-326 | Human | ↑ | CD47 | Promote phagocytosis of myelin | [80] |
CSF | |||||
 miR-922 | Human | ↓ | ND | ND | [54] |
 miR-181c, miR-633 | Human | ↑ | |||
 miR-219 | Human | ↓ | ND | ND | [55] |
 miR-150 | Human | ↑ | ND | ND | [56] |
Demyelinated MS hippocampi | |||||
 miR-124 | Human | ↑ | AMPA2 | ND | [96] |
AMPA3 |