TY - JOUR AU - Franceschi, C. AU - Bonafe, M. AU - Valensin, S. AU - Olivieri, F. AU - Luca, M. AU - Ottaviani, E. PY - 2000 DA - 2000// TI - Inflamm-aging. An evolutionary perspective on immunosenescence JO - Ann N Y Acad Sci VL - 908 UR - https://doi.org/10.1111/j.1749-6632.2000.tb06651.x DO - 10.1111/j.1749-6632.2000.tb06651.x ID - Franceschi2000 ER - TY - JOUR AU - Baylis, D. AU - Bartlett, D. B. AU - Patel, H. P. AU - Roberts, H. C. PY - 2013 DA - 2013// TI - Understanding how we age: insights into inflammaging JO - Longevity & Healthspan VL - 2 UR - https://doi.org/10.1186/2046-2395-2-8 DO - 10.1186/2046-2395-2-8 ID - Baylis2013 ER - TY - JOUR AU - Xia, S. AU - Zhang, X. AU - Zheng, S. AU - Khanabdali, R. AU - Kalionis, B. AU - Wu, J. PY - 2016 DA - 2016// TI - An update on Inflamm-aging: mechanisms, prevention, and treatment JO - J Immunol Res VL - 2016 UR - https://doi.org/10.1155/2016/8426874 DO - 10.1155/2016/8426874 ID - Xia2016 ER - TY - JOUR AU - Kaptoge, S. AU - Angelantonio, E. AU - Lowe, G. AU - Pepys, M. B. AU - Thompson, S. G. AU - Collins, R. PY - 2010 DA - 2010// TI - C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: an individual participant meta-analysis JO - Lancet (London, England) VL - 375 UR - https://doi.org/10.1016/S0140-6736(09)61717-7 DO - 10.1016/S0140-6736(09)61717-7 ID - Kaptoge2010 ER - TY - JOUR AU - Puzianowska-Kuźnicka, M. AU - Owczarz, M. AU - Wieczorowska-Tobis, K. AU - Nadrowski, P. AU - Chudek, J. AU - Slusarczyk, P. PY - 2016 DA - 2016// TI - Interleukin-6 and C-reactive protein, successful aging, and mortality: the PolSenior study JO - Immunity & Ageing : I & A VL - 13 UR - https://doi.org/10.1186/s12979-016-0076-x DO - 10.1186/s12979-016-0076-x ID - Puzianowska-Kuźnicka2016 ER - TY - JOUR AU - Fougere, B. AU - Boulanger, E. AU - Nourhashemi, F. AU - Guyonnet, S. AU - Cesari, M. PY - 2017 DA - 2017// TI - Chronic inflammation: accelerator of biological aging JO - J Gerontol A Biol Sci Med Sci VL - 72 UR - https://doi.org/10.1093/gerona/glw240 DO - 10.1093/gerona/glw240 ID - Fougere2017 ER - TY - JOUR AU - Singh, T. AU - Newman, A. B. PY - 2011 DA - 2011// TI - Inflammatory markers in population studies of aging JO - Ageing Res Rev VL - 10 UR - https://doi.org/10.1016/j.arr.2010.11.002 DO - 10.1016/j.arr.2010.11.002 ID - Singh2011 ER - TY - JOUR AU - Bonafe, M. AU - Olivieri, F. AU - Cavallone, L. AU - Giovagnetti, S. AU - Mayegiani, F. AU - Cardelli, M. PY - 2001 DA - 2001// TI - A gender--dependent genetic predisposition to produce high levels of IL-6 is detrimental for longevity JO - Eur J Immunol VL - 31 UR - https://doi.org/3.0.CO;2-X DO - 3.0.CO;2-X ID - Bonafe2001 ER - TY - JOUR AU - Suk, H. J. AU - Ridker, P. M. AU - Cook, N. R. AU - Zee, R. Y. PY - 2005 DA - 2005// TI - Relation of polymorphism within the C-reactive protein gene and plasma CRP levels JO - Atherosclerosis VL - 178 UR - https://doi.org/10.1016/j.atherosclerosis.2004.07.033 DO - 10.1016/j.atherosclerosis.2004.07.033 ID - Suk2005 ER - TY - JOUR AU - Vickers, M. A. AU - Green, F. R. AU - Terry, C. AU - Mayosi, B. M. AU - Julier, C. AU - Lathrop, M. PY - 2002 DA - 2002// TI - Genotype at a promoter polymorphism of the interleukin-6 gene is associated with baseline levels of plasma C-reactive protein JO - Cardiovasc Res VL - 53 UR - https://doi.org/10.1016/S0008-6363(01)00534-X DO - 10.1016/S0008-6363(01)00534-X ID - Vickers2002 ER - TY - STD TI - Horvath S. DNA methylation age of human tissues and cell types. Genome Biol. 2013;14(10):R115. ID - ref11 ER - TY - STD TI - Hannum G, Guinney J, Zhao L, Zhang L, Hughes G, Sadda S, et al. Genome-wide methylation profiles reveal quantitative views of human aging rates. Mol Cell. 2013;49(2):359–67. ID - ref12 ER - TY - JOUR AU - Breitling, L. P. AU - Saum, K. U. AU - Perna, L. AU - Schottker, B. AU - Holleczek, B. AU - Brenner, H. PY - 2016 DA - 2016// TI - Frailty is associated with the epigenetic clock but not with telomere length in a German cohort JO - Clin Epigenetics VL - 8 UR - https://doi.org/10.1186/s13148-016-0186-5 DO - 10.1186/s13148-016-0186-5 ID - Breitling2016 ER - TY - JOUR AU - Levine, M. E. AU - Hosgood, H. D. AU - Chen, B. AU - Absher, D. AU - Assimes, T. AU - Horvath, S. PY - 2015 DA - 2015// TI - DNA methylation age of blood predicts future onset of lung cancer in the women’s health initiative JO - Aging (Albany NY) VL - 7 UR - https://doi.org/10.18632/aging.100809 DO - 10.18632/aging.100809 ID - Levine2015 ER - TY - JOUR AU - Horvath, S. AU - Ritz, B. R. PY - 2015 DA - 2015// TI - Increased epigenetic age and granulocyte counts in the blood of Parkinson’s disease patients JO - Aging (Albany NY) VL - 7 UR - https://doi.org/10.18632/aging.100859 DO - 10.18632/aging.100859 ID - Horvath2015 ER - TY - JOUR AU - Chen, B. H. AU - Marioni, R. E. AU - Colicino, E. AU - Peters, M. J. AU - Ward-Caviness, C. K. AU - Tsai, P. -. C. PY - 2016 DA - 2016// TI - DNA methylation-based measures of biological age: meta-analysis predicting time to death JO - Aging (Albany NY) VL - 8 UR - https://doi.org/10.18632/aging.101020 DO - 10.18632/aging.101020 ID - Chen2016 ER - TY - JOUR AU - Marioni, R. E. AU - Shah, S. AU - McRae, A. F. AU - Ritchie, S. J. AU - Muniz-Terrera, G. AU - Harris, S. E. PY - 2015 DA - 2015// TI - The epigenetic clock is correlated with physical and cognitive fitness in the Lothian Birth Cohort 1936 JO - Int J Epidemiol VL - 44 UR - https://doi.org/10.1093/ije/dyu277 DO - 10.1093/ije/dyu277 ID - Marioni2015 ER - TY - STD TI - Lassale C, Batty GD, Steptoe A, Cadar D, Akbaraly TN, Kivimaki M, et al. Association of 10-year C-reactive protein trajectories with markers of healthy aging: findings from the English Longitudinal Study of Ageing. The journals of gerontology Series A, Biological sciences and medical sciences. 2018. ID - ref18 ER - TY - JOUR AU - Ferrucci, L. AU - Corsi, A. AU - Lauretani, F. AU - Bandinelli, S. AU - Bartali, B. AU - Taub, D. D. PY - 2005 DA - 2005// TI - The origins of age-related proinflammatory state JO - Blood VL - 105 UR - https://doi.org/10.1182/blood-2004-07-2599 DO - 10.1182/blood-2004-07-2599 ID - Ferrucci2005 ER - TY - JOUR AU - Eklund, C. M. PY - 2009 DA - 2009// TI - Proinflammatory cytokines in CRP baseline regulation JO - Adv Clin Chem VL - 48 UR - https://doi.org/10.1016/S0065-2423(09)48005-3 DO - 10.1016/S0065-2423(09)48005-3 ID - Eklund2009 ER - TY - JOUR AU - Fulop, T. AU - Larbi, A. AU - Dupuis, G. AU - Page, A. AU - Frost, E. H. AU - Cohen, A. A. PY - 2017 DA - 2017// TI - Immunosenescence and inflamm-aging as two sides of the same coin: friends or foes? JO - Front Immunol VL - 8 UR - https://doi.org/10.3389/fimmu.2017.01960 DO - 10.3389/fimmu.2017.01960 ID - Fulop2017 ER - TY - JOUR AU - Franceschi, C. AU - Campisi, J. PY - 2014 DA - 2014// TI - Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases JO - J Gerontol A Biol Sci Med Sci VL - 69 UR - https://doi.org/10.1093/gerona/glu057 DO - 10.1093/gerona/glu057 ID - Franceschi2014 ER - TY - JOUR AU - Wyczalkowska-Tomasik, A. AU - Czarkowska-Paczek, B. AU - Zielenkiewicz, M. AU - Paczek, L. PY - 2016 DA - 2016// TI - Inflammatory markers change with age, but do not fall beyond reported normal ranges JO - Arch Immunol Ther Exp VL - 64 UR - https://doi.org/10.1007/s00005-015-0357-7 DO - 10.1007/s00005-015-0357-7 ID - Wyczalkowska-Tomasik2016 ER - TY - JOUR AU - Franceschi, C. AU - Valensin, S. AU - Bonafe, M. AU - Paolisso, G. AU - Yashin, A. I. AU - Monti, D. PY - 2000 DA - 2000// TI - The network and the remodeling theories of aging: historical background and new perspectives JO - Exp Gerontol VL - 35 UR - https://doi.org/10.1016/S0531-5565(00)00172-8 DO - 10.1016/S0531-5565(00)00172-8 ID - Franceschi2000 ER - TY - JOUR AU - Lu, A. T. AU - Xue, L. AU - Salfati, E. L. AU - Chen, B. H. AU - Ferrucci, L. AU - Levy, D. PY - 2018 DA - 2018// TI - GWAS of epigenetic aging rates in blood reveals a critical role for TERT JO - Nat Commun VL - 9 UR - https://doi.org/10.1038/s41467-017-02697-5 DO - 10.1038/s41467-017-02697-5 ID - Lu2018 ER - TY - JOUR AU - Irvin, M. R. AU - Aslibekyan, S. AU - Do, A. AU - Zhi, D. AU - Hidalgo, B. AU - Claas, S. A. PY - 2018 DA - 2018// TI - Metabolic and inflammatory biomarkers are associated with epigenetic aging acceleration estimates in the GOLDN study JO - Clin Epigenetics VL - 10 UR - https://doi.org/10.1186/s13148-018-0481-4 DO - 10.1186/s13148-018-0481-4 ID - Irvin2018 ER - TY - CHAP AU - Zhang, Q. AU - Vallerga, C. AU - Walker, R. AU - Lin, T. AU - Henders, A. AU - Montgomery, G. PY - 2018 DA - 2018// TI - Improved prediction of chronological age from DNA methylation limits it as a biomarker of ageing BT - bioRxiv ID - Zhang2018 ER - TY - JOUR AU - Deary, I. J. AU - Gow, A. J. AU - Pattie, A. AU - Starr, J. M. PY - 2012 DA - 2012// TI - Cohort profile: the Lothian Birth Cohorts of 1921 and 1936 JO - Int J Epidemiol VL - 41 UR - https://doi.org/10.1093/ije/dyr197 DO - 10.1093/ije/dyr197 ID - Deary2012 ER - TY - JOUR AU - Taylor, A. M. AU - Pattie, A. AU - Deary, I. J. PY - 2018 DA - 2018// TI - Cohort profile update: the Lothian Birth Cohorts of 1921 and 1936 JO - Int J Epidemiol VL - 41 ID - Taylor2018 ER - TY - JOUR AU - Aribisala, B. S. AU - Wiseman, S. AU - Morris, Z. AU - Valdes-Hernandez, M. C. AU - Royle, N. A. AU - Maniega, S. M. PY - 2014 DA - 2014// TI - Circulating inflammatory markers are associated with magnetic resonance imaging-visible perivascular spaces but not directly with white matter hyperintensities JO - Stroke VL - 45 UR - https://doi.org/10.1161/STROKEAHA.113.004059 DO - 10.1161/STROKEAHA.113.004059 ID - Aribisala2014 ER - TY - JOUR AU - Mõttus, R. AU - Luciano, M. AU - Starr, J. M. AU - Pollard, M. C. AU - Deary, I. J. PY - 2013 DA - 2013// TI - Personality traits and inflammation in men and women in their early 70s JO - Psychosom Med VL - 75 UR - https://doi.org/10.1097/PSY.0b013e31827576cc DO - 10.1097/PSY.0b013e31827576cc ID - Mõttus2013 ER - TY - JOUR AU - Houseman, E. A. AU - Accomando, W. P. AU - Koestler, D. C. AU - Christensen, B. C. AU - Marsit, C. J. AU - Nelson, H. H. PY - 2012 DA - 2012// TI - DNA methylation arrays as surrogate measures of cell mixture distribution JO - BMC bioinformatics VL - 13 UR - https://doi.org/10.1186/1471-2105-13-86 DO - 10.1186/1471-2105-13-86 ID - Houseman2012 ER - TY - JOUR AU - Horvath, S. AU - Levine, A. J. PY - 2015 DA - 2015// TI - HIV-1 infection accelerates age according to the epigenetic clock JO - J Infect Dis VL - 212 UR - https://doi.org/10.1093/infdis/jiv277 DO - 10.1093/infdis/jiv277 ID - Horvath2015 ER - TY - JOUR AU - Horvath, S. AU - Gurven, M. AU - Levine, M. E. AU - Trumble, B. C. AU - Kaplan, H. AU - Allayee, H. PY - 2016 DA - 2016// TI - An epigenetic clock analysis of race/ethnicity, sex, and coronary heart disease JO - Genome Biol VL - 17 UR - https://doi.org/10.1186/s13059-016-1030-0 DO - 10.1186/s13059-016-1030-0 ID - Horvath2016 ER - TY - JOUR AU - Klemera, P. AU - Doubal, S. PY - 2006 DA - 2006// TI - A new approach to the concept and computation of biological age JO - Mech Ageing Dev VL - 127 UR - https://doi.org/10.1016/j.mad.2005.10.004 DO - 10.1016/j.mad.2005.10.004 ID - Klemera2006 ER - TY - STD TI - Kuznetsova A, Brockhoff PB, Christensen RHB. lmerTest: Tests in Linear Mixed Effects Models. R package version 2.0-33. 2016. ID - ref36 ER - TY - STD TI - R Core Team. R: a language and environment for statistical computing. Vienna, R Foundation for Statistical Computing; 2018. ID - ref37 ER -