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Table 2 Multi-variable linear regression coefficients of clinical features with DNAm age residuals for NN, PN, and PP

From: DNA methylation age is not affected in psoriatic skin tissue

Statistics Estimate Std. error t value Pr (>|t|)
1) Model for NN: age acceleration residual~age + BMI + gender + smoking status
 Intercept* − 0.764 7.678 − 0.100 9.21E-01
 Age − 0.038 0.068 − 0.556 5.80E-01
 BMI 0.200 0.352 0.569 5.72E-01
 Gender (female vs. male) − 0.830 1.863 − 0.446 6.58E-01
 Smoking status (current vs. former) −1.789 3.067 − 0.583 5.62E-01
 Smoking status (current vs. never) − 0.803 2.123 − 0.378 7.07E-01
2) Model for PN: age acceleration residual~age + BMI + gender + smoking status
 Intercept − 8.309 4.561 − 1.822 7.70E-02
 Age 0.138 0.034 4.074 2.52E-04
 BMI 0.125 0.206 0.607 5.48E-01
 Gender (female vs. male) − 1.688 0.975 − 1.732 9.21E-02
 Smoking status (current vs. former) − 2.745 1.865 −1.472 1.50E-01
 Smoking status (current vs. never) 0.536 1.222 0.438 6.64E-01
3) Model for PP: age acceleration residual~age + BMI + gender + smoking status + PASI
 Intercept 6.266 6.644 0.943 3.47E-01
 Age − 0.032 0.053 − 0.605 5.47E-01
 BMI − 0.196 0.286 − 0.685 4.95E-01
 Gender (female vs. male) − 1.173 1.656 − 0.708 4.80E-01
 PASI scores − 0.255 0.198 − 1.289 2.00E-01
 Smoking status (current vs. former) 3.780 2.567 1.472 1.43E-01
 Smoking status (current vs. never) 0.573 2.019 0.284 7.77E-01
  1. *Intercept is the constant term of a regression model. Here, it denotes the corresponding value of age acceleration residual when all the independent variables are 0