Table 2 Multi-variable linear regression coefficients of clinical features with DNAm age residuals for NN, PN, and PP
From: DNA methylation age is not affected in psoriatic skin tissue
Statistics | Estimate | Std. error | t value | Pr (>|t|) |
|---|---|---|---|---|
1) Model for NN: age acceleration residual~age + BMI + gender + smoking status | ||||
 Intercept* | − 0.764 | 7.678 | − 0.100 | 9.21E-01 |
 Age | − 0.038 | 0.068 | − 0.556 | 5.80E-01 |
 BMI | 0.200 | 0.352 | 0.569 | 5.72E-01 |
 Gender (female vs. male) | − 0.830 | 1.863 | − 0.446 | 6.58E-01 |
 Smoking status (current vs. former) | −1.789 | 3.067 | − 0.583 | 5.62E-01 |
 Smoking status (current vs. never) | − 0.803 | 2.123 | − 0.378 | 7.07E-01 |
2) Model for PN: age acceleration residual~age + BMI + gender + smoking status | ||||
 Intercept | − 8.309 | 4.561 | − 1.822 | 7.70E-02 |
 Age | 0.138 | 0.034 | 4.074 | 2.52E-04 |
 BMI | 0.125 | 0.206 | 0.607 | 5.48E-01 |
 Gender (female vs. male) | − 1.688 | 0.975 | − 1.732 | 9.21E-02 |
 Smoking status (current vs. former) | − 2.745 | 1.865 | −1.472 | 1.50E-01 |
 Smoking status (current vs. never) | 0.536 | 1.222 | 0.438 | 6.64E-01 |
3) Model for PP: age acceleration residual~age + BMI + gender + smoking status + PASI | ||||
 Intercept | 6.266 | 6.644 | 0.943 | 3.47E-01 |
 Age | − 0.032 | 0.053 | − 0.605 | 5.47E-01 |
 BMI | − 0.196 | 0.286 | − 0.685 | 4.95E-01 |
 Gender (female vs. male) | − 1.173 | 1.656 | − 0.708 | 4.80E-01 |
 PASI scores | − 0.255 | 0.198 | − 1.289 | 2.00E-01 |
 Smoking status (current vs. former) | 3.780 | 2.567 | 1.472 | 1.43E-01 |
 Smoking status (current vs. never) | 0.573 | 2.019 | 0.284 | 7.77E-01 |