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Fig. 4 | Clinical Epigenetics

Fig. 4

From: Differential open chromatin profile and transcriptomic signature define depot-specific human subcutaneous preadipocytes: primary outcomes

Fig. 4

Identification of the putative regulatory regions of depot-specific genes. a Depot-specific open chromatin regions determined by ATAC-seq were annotated to the nearest depot-specific genes in a ± 100-kb genomic region relative to the transcription start sites (TSSs) and (transcription termination site (TTS)). b Volcano plots portray the depot-specific open chromatin regions annotated to the abdominal- (left graph) and GF-specific genes (right graph). Abdominal-specific open chromatin regions are highlighted in red, while GF-specific open chromatin regions are highlighted in green. c Motif analysis of the 159 abdominal-specific open chromatin regions annotated to abdominal specific genes. Enriched motif matrices are presented along with the p values; the percentages of each motif are found in the target (Target%) and background (Bg%) genomic regions

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