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Table 4 Genomic regions with methylation differences > 5% between pre- and post-pubertal control groups

From: Methylome profiling of healthy and central precocious puberty girls

DMR identification Chromosome DMR start DMR end Number of CpGs Mean beta difference (pre-pubertal minus post-pubertal values) Promoters of genes included in the genomic region
DMR_1372 10 42,862,876 42,863,594 9 − 0.105162452 RP11-313 J2.1
DMR_8814 4 81,117,647 81,119,473 11 − 0.089040315 PRDM8
DMR_4264 16 1,583,810 1,584,516 8 − 0.084174074 IFT140, TMEM204
DMR_11738 X 48,814,205 48,815,856 16 − 0.08181042 OTUD5, RNU6-722P
DMR_9935 6 31,148,332 31,148,748 14 − 0.078236383 POU5F1
DMR_12001 X 153,671,800 153,672,898 8 − 0.076624259 FAM50A, GDI1
DMR_11933 X 132,090,860 132,092,772 7 − 0.075099028 HS6ST2
DMR_11979 X 152,066,221 152,066,735 7 − 0.073224659 NA
DMR_11993 X 153,598,742 153,600,494 7 − 0.072362363 FLNA
DMR_11972 X 149,861,526 149,862,363 7 − 0.070984952 MTMR1
DMR_9959 6 31,650,735 31,651,362 18 − 0.070185244 LY6G5C
DMR_10023 6 33,047,185 33,049,505 22 − 0.069255178 HLA-DPB1, HLA-DPA1, RPL32P1
DMR_11751 X 49,643,431 49,644,706 7 − 0.067077238 USP27X-AS1, USP27X
DMR_11804 X 71,130,538 71,131,891 7 − 0.066738144 NHSL2
DMR_11950 X 135,578,793 135,580,181 18 − 0.063932352 HTATSF1
DMR_7255 20 5,485,144 5,485,511 8 − 0.062564433 LINC00654
DMR_3109 12 130,823,570 130,824,831 8 − 0.062155177 PIWIL1
DMR_11802 X 70,712,403 70,713,213 8 − 0.0621177 INGX, Y_RNA.73, TAF1
DMR_11934 X 133,118,088 133,119,961 11 − 0.061748623 GPC3
DMR_12006 X 153,774,721 153,776,358 18 − 0.061612111 IKBKG, G6PD
DMR_5381 17 78,865,087 78,865,755 7 − 0.061329072 NA
DMR_11732 X 48,554,185 48,555,977 7 − 0.061177896 SUV39H1
DMR_11995 X 153,605,635 153,607,981 9 − 0.061083719 EMD
DMR_11921 X 129,114,238 129,118,953 19 − 0.060957678 BCORL1
DMR_11500 8 144,789,164 144,790,772 9 − 0.060451112 ZNF707, CCDC166
DMR_9283 5 77,145,356 77,147,141 8 − 0.060227285 NA
DMR_11790 X 68,723,670 68,725,815 13 − 0.06007949 FAM155B, AL158069.1
DMR_11669 X 21,391,817 21,393,898 12 − 0.059401453 CNKSR2
DMR_11823 X 79,590,789 79,591,032 8 − 0.059246208 FAM46D
DMR_11821 X 77,358,961 77,360,510 14 − 0.059121003 PGK1
DMR_11666 X 19,533,022 19,534,066 10 − 0.058953271 MAP3K15
DMR_11670 X 21,674,815 21,677,134 14 − 0.058921343 KLHL34
DMR_11678 X 24,482,846 24,484,361 10 − 0.058918654 PDK3
DMR_11711 X 46,432,770 46,434,442 9 − 0.058894854 CHST7
DMR_9843 6 28,601,271 28,601,519 11 − 0.05882722 RP11-373 N24.2
DMR_11966 X 147,581,562 147,583,550 15 − 0.058723364 AFF2, AC002368.4
DMR_11659 X 17,392,798 17,393,584 7 − 0.058571815 NHS
DMR_11900 X 119,005,413 119,006,837 14 − 0.058548975 NDUFA1, RNF113A
DMR_11742 X 48,931,388 48,932,122 11 − 0.058333756 PRAF2, WDR45
DMR_12004 X 153,718,691 153,719,406 10 − 0.058126507 SLC10A3
DMR_11999 X 153,656,860 153,657,411 7 − 0.058031895 BX936347.1, ATP6AP1
DMR_11748 X 49,056,505 49,057,013 9 − 0.058008258 SYP, SYP-AS1
DMR_2557 12 9,217,079 9,217,907 11 − 0.057945682 A2M-AS1, LINC00612
DMR_11970 X 149,529,976 149,534,258 17 − 0.057730577 MAMLD1
DMR_5006 17 37,123,638 37,124,558 10 − 0.057306128 FBXO47
DMR_6288 19 54,040,774 54,041,856 10 − 0.057304041 ZNF331
DMR_11944 X 134,232,157 134,233,109 7 − 0.057092491 LINC00087
DMR_11957 X 138,285,393 138,287,900 17 − 0.056982737 FGF13
DMR_11888 X 118,107,540 118,110,766 16 − 0.056978196 LONRF3
DMR_11764 X 54,383,906 54,385,662 7 − 0.056970851 WNK3
DMR_12003 X 153,713,930 153,715,426 10 − 0.05672695 UBL4A
DMR_11994 X 153,602,509 153,603,503 11 − 0.056715308 FLNA
DMR_11991 X 153,284,899 153,285,934 7 − 0.056647889 IRAK1, MIR718
DMR_11693 X 38,420,326 38,421,503 11 − 0.056490464 TSPAN7
DMR_11668 X 20,283,423 20,286,779 12 − 0.056376843 RPS6KA3
DMR_11672 X 21,958,416 21,959,700 10 − 0.056271754 SMS, LL0XNC01-39B3.1
DMR_1702 10 123,355,268 123,358,317 17 − 0.056225675 FGFR2
DMR_11974 X 150,150,670 150,153,136 17 − 0.056110647 HMGB3
DMR_11919 X 128,977,299 128,978,347 14 − 0.055916881 ZDHHC9
DMR_11770 X 55,187,242 55,187,903 10 − 0.055775168 FAM104B
DMR_7483 20 57,425,157 57,428,473 65 − 0.05557006 GNAS, GNAS-AS1
DMR_9132 5 23,507,030 23,507,656 7 − 0.055437765 PRDM9
DMR_11978 X 151,999,239 152,000,347 12 − 0.055139575 NSDHL, CETN2
DMR_12000 X 153,664,475 153,665,799 9 − 0.055090146 GDI1
DMR_11729 X 48,432,279 48,433,876 12 − 0.054825597 RBM3, AC115618.1
DMR_10691 7 50,849,168 50,851,503 9 − 0.054780529 GRB10
DMR_11873 X 107,334,429 107,335,227 11 − 0.054776826 PSMD10, ATG4A
DMR_11984 X 152,906,667 152,910,369 14 − 0.054741445 DUSP9
DMR_11642 X 11,774,782 11,777,794 18 − 0.054708295 MSL3
DMR_1209 1 240,656,217 240,657,329 8 − 0.054513802 NA
DMR_11894 X 118,707,913 118,709,261 14 − 0.054314233 UBE2A
DMR_11684 X 30,326,328 30,327,819 14 − 0.053883806 NR0B1
DMR_4794 17 6,898,738 6,899,888 15 − 0.053689222 ALOX12, RP11-589P10.5
DMR_11998 X 153,639,287 153,640,967 12 − 0.053584581 DNASE1L1, TAZ
DMR_11725 X 47,862,977 47,863,707 8 − 0.05357646 SPACA5, ZNF182
DMR_11648 X 15,353,254 15,354,150 12 − 0.053561291 PIGA
DMR_11911 X 122,993,419 122,994,594 14 − 0.053524318 XIAP
DMR_11743 X 48,957,691 48,958,509 12 − 0.053409715 WDR45
DMR_11741 X 48,900,948 48,901,982 9 − 0.053374186 TFE3
DMR_11915 X 128,656,725 128,657,893 11 − 0.053357781 SMARCA1
DMR_7894 22 51,016,501 51,017,151 12 − 0.053231588 CPT1B, CHKB-CPT1B, CHKB
DMR_11942 X 134,165,954 134,166,347 7 − 0.053015868 FAM127A
DMR_11720 X 47,478,591 47,479,662 11 − 0.052859687 SYN1
DMR_11777 X 62,974,433 62,975,657 10 − 0.052826713 ARHGEF9
DMR_11903 X 119,148,809 119,150,375 8 − 0.052776664 GS1-421I3.2
DMR_11918 X 128,913,578 128,913,980 7 − 0.052666423 SASH3
DMR_11923 X 129,243,062 129,246,153 12 − 0.05258674 ELF4
DMR_10704 7 56,515,510 56,516,504 10 − 0.052581782 RP13-492C18.2
DMR_11996 X 153,625,785 153,628,595 17 − 0.052516898 RPL10, SNORA70
DMR_12002 X 153,707,029 153,708,103 8 − 0.052282548 LAGE3
DMR_11892 X 118,601,891 118,603,378 9 − 0.052141155 SLC25A5, SLC25A5-AS1
DMR_11890 X 118,369,571 118,370,873 12 − 0.05200566 PGRMC1
DMR_11977 X 151,806,225 151,807,197 11 − 0.051997479 GABRQ
DMR_11781 X 64,254,409 64,255,552 7 − 0.051933195 ZC4H2
DMR_9869 6 29,629,187 29,631,447 10 − 0.051487467 NA
DMR_11852 X 101,966,398 101,967,643 8 − 0.051470117 GPRASP2
DMR_11718 X 47,341,740 47,343,198 13 − 0.051358132 ZNF41, CXorf24
DMR_11677 X 23,925,454 23,927,284 12 − 0.051200853 CXorf58, APOO
DMR_9823 6 28,058,715 28,059,208 9 − 0.051119312 ZSCAN12P1
DMR_11703 X 41,781,891 41,783,785 10 − 0.05111124 CASK
DMR_11675 X 23,760,460 23,762,372 13 − 0.051058352 ACOT9
DMR_11714 X 47,003,362 47,004,911 16 − 0.051047155 NDUFB11, RBM10
DMR_11834 X 99,661,860 99,667,528 23 − 0.051019999 PCDH19
DMR_9036 4 174,421,114 174,422,908 9 − 0.050942397 NA
DMR_11955 X 136,647,133 136,649,808 10 − 0.050903123 ZIC3, RP1-137H15.2
DMR_11909 X 119,763,444 119,764,469 11 − 0.050899975 C1GALT1C1
DMR_10849 7 100,463,206 100,465,221 11 − 0.050845841 TRIP6
DMR_4309 16 3,493,133 3,494,155 12 − 0.050709712 ZNF597, NAA60
DMR_11695 X 38,662,279 38,665,168 16 − 0.050532132 MID1IP1, MID1IP1-AS1
DMR_11785 X 67,653,156 67,653,925 10 − 0.050494689 OPHN1
DMR_12009 X 154,032,629 154,034,184 11 − 0.050494431 MPP1
DMR_11922 X 129,193,893 129,194,982 7 − 0.050454357 NA
DMR_5488 18 14,747,888 14,748,439 10 − 0.050398645 ANKRD30B
DMR_11851 X 101,905,837 101,907,254 8 − 0.050370988 GPRASP1
DMR_12011 X 154,299,274 154,300,204 8 − 0.050341015 BRCC3, MTCP1, CMC4
DMR_4813 17 7,311,030 7,312,081 9 − 0.05032058 NLGN2
DMR_11673 X 23,350,093 23,353,620 13 − 0.050150411 PTCHD1
DMR_11763 X 54,209,148 54,209,968 8 − 0.050134574 FAM120C
DMR_11902 X 119,133,852 119,135,074 7 − 0.050060465 NA
DMR_9870 6 29,648,161 29,649,084 22 0.08795856 ZFP57
  1. Abbreviations: DMR differentially methylated region, NA not available