Table 4 Genomic regions with methylation differences > 5% between pre- and post-pubertal control groups
From: Methylome profiling of healthy and central precocious puberty girls
DMR identification | Chromosome | DMR start | DMR end | Number of CpGs | Mean beta difference (pre-pubertal minus post-pubertal values) | Promoters of genes included in the genomic region |
|---|---|---|---|---|---|---|
DMR_1372 | 10 | 42,862,876 | 42,863,594 | 9 | − 0.105162452 | RP11-313 J2.1 |
DMR_8814 | 4 | 81,117,647 | 81,119,473 | 11 | − 0.089040315 | PRDM8 |
DMR_4264 | 16 | 1,583,810 | 1,584,516 | 8 | − 0.084174074 | IFT140, TMEM204 |
DMR_11738 | X | 48,814,205 | 48,815,856 | 16 | − 0.08181042 | OTUD5, RNU6-722P |
DMR_9935 | 6 | 31,148,332 | 31,148,748 | 14 | − 0.078236383 | POU5F1 |
DMR_12001 | X | 153,671,800 | 153,672,898 | 8 | − 0.076624259 | FAM50A, GDI1 |
DMR_11933 | X | 132,090,860 | 132,092,772 | 7 | − 0.075099028 | HS6ST2 |
DMR_11979 | X | 152,066,221 | 152,066,735 | 7 | − 0.073224659 | NA |
DMR_11993 | X | 153,598,742 | 153,600,494 | 7 | − 0.072362363 | FLNA |
DMR_11972 | X | 149,861,526 | 149,862,363 | 7 | − 0.070984952 | MTMR1 |
DMR_9959 | 6 | 31,650,735 | 31,651,362 | 18 | − 0.070185244 | LY6G5C |
DMR_10023 | 6 | 33,047,185 | 33,049,505 | 22 | − 0.069255178 | HLA-DPB1, HLA-DPA1, RPL32P1 |
DMR_11751 | X | 49,643,431 | 49,644,706 | 7 | − 0.067077238 | USP27X-AS1, USP27X |
DMR_11804 | X | 71,130,538 | 71,131,891 | 7 | − 0.066738144 | NHSL2 |
DMR_11950 | X | 135,578,793 | 135,580,181 | 18 | − 0.063932352 | HTATSF1 |
DMR_7255 | 20 | 5,485,144 | 5,485,511 | 8 | − 0.062564433 | LINC00654 |
DMR_3109 | 12 | 130,823,570 | 130,824,831 | 8 | − 0.062155177 | PIWIL1 |
DMR_11802 | X | 70,712,403 | 70,713,213 | 8 | − 0.0621177 | INGX, Y_RNA.73, TAF1 |
DMR_11934 | X | 133,118,088 | 133,119,961 | 11 | − 0.061748623 | GPC3 |
DMR_12006 | X | 153,774,721 | 153,776,358 | 18 | − 0.061612111 | IKBKG, G6PD |
DMR_5381 | 17 | 78,865,087 | 78,865,755 | 7 | − 0.061329072 | NA |
DMR_11732 | X | 48,554,185 | 48,555,977 | 7 | − 0.061177896 | SUV39H1 |
DMR_11995 | X | 153,605,635 | 153,607,981 | 9 | − 0.061083719 | EMD |
DMR_11921 | X | 129,114,238 | 129,118,953 | 19 | − 0.060957678 | BCORL1 |
DMR_11500 | 8 | 144,789,164 | 144,790,772 | 9 | − 0.060451112 | ZNF707, CCDC166 |
DMR_9283 | 5 | 77,145,356 | 77,147,141 | 8 | − 0.060227285 | NA |
DMR_11790 | X | 68,723,670 | 68,725,815 | 13 | − 0.06007949 | FAM155B, AL158069.1 |
DMR_11669 | X | 21,391,817 | 21,393,898 | 12 | − 0.059401453 | CNKSR2 |
DMR_11823 | X | 79,590,789 | 79,591,032 | 8 | − 0.059246208 | FAM46D |
DMR_11821 | X | 77,358,961 | 77,360,510 | 14 | − 0.059121003 | PGK1 |
DMR_11666 | X | 19,533,022 | 19,534,066 | 10 | − 0.058953271 | MAP3K15 |
DMR_11670 | X | 21,674,815 | 21,677,134 | 14 | − 0.058921343 | KLHL34 |
DMR_11678 | X | 24,482,846 | 24,484,361 | 10 | − 0.058918654 | PDK3 |
DMR_11711 | X | 46,432,770 | 46,434,442 | 9 | − 0.058894854 | CHST7 |
DMR_9843 | 6 | 28,601,271 | 28,601,519 | 11 | − 0.05882722 | RP11-373 N24.2 |
DMR_11966 | X | 147,581,562 | 147,583,550 | 15 | − 0.058723364 | AFF2, AC002368.4 |
DMR_11659 | X | 17,392,798 | 17,393,584 | 7 | − 0.058571815 | NHS |
DMR_11900 | X | 119,005,413 | 119,006,837 | 14 | − 0.058548975 | NDUFA1, RNF113A |
DMR_11742 | X | 48,931,388 | 48,932,122 | 11 | − 0.058333756 | PRAF2, WDR45 |
DMR_12004 | X | 153,718,691 | 153,719,406 | 10 | − 0.058126507 | SLC10A3 |
DMR_11999 | X | 153,656,860 | 153,657,411 | 7 | − 0.058031895 | BX936347.1, ATP6AP1 |
DMR_11748 | X | 49,056,505 | 49,057,013 | 9 | − 0.058008258 | SYP, SYP-AS1 |
DMR_2557 | 12 | 9,217,079 | 9,217,907 | 11 | − 0.057945682 | A2M-AS1, LINC00612 |
DMR_11970 | X | 149,529,976 | 149,534,258 | 17 | − 0.057730577 | MAMLD1 |
DMR_5006 | 17 | 37,123,638 | 37,124,558 | 10 | − 0.057306128 | FBXO47 |
DMR_6288 | 19 | 54,040,774 | 54,041,856 | 10 | − 0.057304041 | ZNF331 |
DMR_11944 | X | 134,232,157 | 134,233,109 | 7 | − 0.057092491 | LINC00087 |
DMR_11957 | X | 138,285,393 | 138,287,900 | 17 | − 0.056982737 | FGF13 |
DMR_11888 | X | 118,107,540 | 118,110,766 | 16 | − 0.056978196 | LONRF3 |
DMR_11764 | X | 54,383,906 | 54,385,662 | 7 | − 0.056970851 | WNK3 |
DMR_12003 | X | 153,713,930 | 153,715,426 | 10 | − 0.05672695 | UBL4A |
DMR_11994 | X | 153,602,509 | 153,603,503 | 11 | − 0.056715308 | FLNA |
DMR_11991 | X | 153,284,899 | 153,285,934 | 7 | − 0.056647889 | IRAK1, MIR718 |
DMR_11693 | X | 38,420,326 | 38,421,503 | 11 | − 0.056490464 | TSPAN7 |
DMR_11668 | X | 20,283,423 | 20,286,779 | 12 | − 0.056376843 | RPS6KA3 |
DMR_11672 | X | 21,958,416 | 21,959,700 | 10 | − 0.056271754 | SMS, LL0XNC01-39B3.1 |
DMR_1702 | 10 | 123,355,268 | 123,358,317 | 17 | − 0.056225675 | FGFR2 |
DMR_11974 | X | 150,150,670 | 150,153,136 | 17 | − 0.056110647 | HMGB3 |
DMR_11919 | X | 128,977,299 | 128,978,347 | 14 | − 0.055916881 | ZDHHC9 |
DMR_11770 | X | 55,187,242 | 55,187,903 | 10 | − 0.055775168 | FAM104B |
DMR_7483 | 20 | 57,425,157 | 57,428,473 | 65 | − 0.05557006 | GNAS, GNAS-AS1 |
DMR_9132 | 5 | 23,507,030 | 23,507,656 | 7 | − 0.055437765 | PRDM9 |
DMR_11978 | X | 151,999,239 | 152,000,347 | 12 | − 0.055139575 | NSDHL, CETN2 |
DMR_12000 | X | 153,664,475 | 153,665,799 | 9 | − 0.055090146 | GDI1 |
DMR_11729 | X | 48,432,279 | 48,433,876 | 12 | − 0.054825597 | RBM3, AC115618.1 |
DMR_10691 | 7 | 50,849,168 | 50,851,503 | 9 | − 0.054780529 | GRB10 |
DMR_11873 | X | 107,334,429 | 107,335,227 | 11 | − 0.054776826 | PSMD10, ATG4A |
DMR_11984 | X | 152,906,667 | 152,910,369 | 14 | − 0.054741445 | DUSP9 |
DMR_11642 | X | 11,774,782 | 11,777,794 | 18 | − 0.054708295 | MSL3 |
DMR_1209 | 1 | 240,656,217 | 240,657,329 | 8 | − 0.054513802 | NA |
DMR_11894 | X | 118,707,913 | 118,709,261 | 14 | − 0.054314233 | UBE2A |
DMR_11684 | X | 30,326,328 | 30,327,819 | 14 | − 0.053883806 | NR0B1 |
DMR_4794 | 17 | 6,898,738 | 6,899,888 | 15 | − 0.053689222 | ALOX12, RP11-589P10.5 |
DMR_11998 | X | 153,639,287 | 153,640,967 | 12 | − 0.053584581 | DNASE1L1, TAZ |
DMR_11725 | X | 47,862,977 | 47,863,707 | 8 | − 0.05357646 | SPACA5, ZNF182 |
DMR_11648 | X | 15,353,254 | 15,354,150 | 12 | − 0.053561291 | PIGA |
DMR_11911 | X | 122,993,419 | 122,994,594 | 14 | − 0.053524318 | XIAP |
DMR_11743 | X | 48,957,691 | 48,958,509 | 12 | − 0.053409715 | WDR45 |
DMR_11741 | X | 48,900,948 | 48,901,982 | 9 | − 0.053374186 | TFE3 |
DMR_11915 | X | 128,656,725 | 128,657,893 | 11 | − 0.053357781 | SMARCA1 |
DMR_7894 | 22 | 51,016,501 | 51,017,151 | 12 | − 0.053231588 | CPT1B, CHKB-CPT1B, CHKB |
DMR_11942 | X | 134,165,954 | 134,166,347 | 7 | − 0.053015868 | FAM127A |
DMR_11720 | X | 47,478,591 | 47,479,662 | 11 | − 0.052859687 | SYN1 |
DMR_11777 | X | 62,974,433 | 62,975,657 | 10 | − 0.052826713 | ARHGEF9 |
DMR_11903 | X | 119,148,809 | 119,150,375 | 8 | − 0.052776664 | GS1-421I3.2 |
DMR_11918 | X | 128,913,578 | 128,913,980 | 7 | − 0.052666423 | SASH3 |
DMR_11923 | X | 129,243,062 | 129,246,153 | 12 | − 0.05258674 | ELF4 |
DMR_10704 | 7 | 56,515,510 | 56,516,504 | 10 | − 0.052581782 | RP13-492C18.2 |
DMR_11996 | X | 153,625,785 | 153,628,595 | 17 | − 0.052516898 | RPL10, SNORA70 |
DMR_12002 | X | 153,707,029 | 153,708,103 | 8 | − 0.052282548 | LAGE3 |
DMR_11892 | X | 118,601,891 | 118,603,378 | 9 | − 0.052141155 | SLC25A5, SLC25A5-AS1 |
DMR_11890 | X | 118,369,571 | 118,370,873 | 12 | − 0.05200566 | PGRMC1 |
DMR_11977 | X | 151,806,225 | 151,807,197 | 11 | − 0.051997479 | GABRQ |
DMR_11781 | X | 64,254,409 | 64,255,552 | 7 | − 0.051933195 | ZC4H2 |
DMR_9869 | 6 | 29,629,187 | 29,631,447 | 10 | − 0.051487467 | NA |
DMR_11852 | X | 101,966,398 | 101,967,643 | 8 | − 0.051470117 | GPRASP2 |
DMR_11718 | X | 47,341,740 | 47,343,198 | 13 | − 0.051358132 | ZNF41, CXorf24 |
DMR_11677 | X | 23,925,454 | 23,927,284 | 12 | − 0.051200853 | CXorf58, APOO |
DMR_9823 | 6 | 28,058,715 | 28,059,208 | 9 | − 0.051119312 | ZSCAN12P1 |
DMR_11703 | X | 41,781,891 | 41,783,785 | 10 | − 0.05111124 | CASK |
DMR_11675 | X | 23,760,460 | 23,762,372 | 13 | − 0.051058352 | ACOT9 |
DMR_11714 | X | 47,003,362 | 47,004,911 | 16 | − 0.051047155 | NDUFB11, RBM10 |
DMR_11834 | X | 99,661,860 | 99,667,528 | 23 | − 0.051019999 | PCDH19 |
DMR_9036 | 4 | 174,421,114 | 174,422,908 | 9 | − 0.050942397 | NA |
DMR_11955 | X | 136,647,133 | 136,649,808 | 10 | − 0.050903123 | ZIC3, RP1-137H15.2 |
DMR_11909 | X | 119,763,444 | 119,764,469 | 11 | − 0.050899975 | C1GALT1C1 |
DMR_10849 | 7 | 100,463,206 | 100,465,221 | 11 | − 0.050845841 | TRIP6 |
DMR_4309 | 16 | 3,493,133 | 3,494,155 | 12 | − 0.050709712 | ZNF597, NAA60 |
DMR_11695 | X | 38,662,279 | 38,665,168 | 16 | − 0.050532132 | MID1IP1, MID1IP1-AS1 |
DMR_11785 | X | 67,653,156 | 67,653,925 | 10 | − 0.050494689 | OPHN1 |
DMR_12009 | X | 154,032,629 | 154,034,184 | 11 | − 0.050494431 | MPP1 |
DMR_11922 | X | 129,193,893 | 129,194,982 | 7 | − 0.050454357 | NA |
DMR_5488 | 18 | 14,747,888 | 14,748,439 | 10 | − 0.050398645 | ANKRD30B |
DMR_11851 | X | 101,905,837 | 101,907,254 | 8 | − 0.050370988 | GPRASP1 |
DMR_12011 | X | 154,299,274 | 154,300,204 | 8 | − 0.050341015 | BRCC3, MTCP1, CMC4 |
DMR_4813 | 17 | 7,311,030 | 7,312,081 | 9 | − 0.05032058 | NLGN2 |
DMR_11673 | X | 23,350,093 | 23,353,620 | 13 | − 0.050150411 | PTCHD1 |
DMR_11763 | X | 54,209,148 | 54,209,968 | 8 | − 0.050134574 | FAM120C |
DMR_11902 | X | 119,133,852 | 119,135,074 | 7 | − 0.050060465 | NA |
DMR_9870 | 6 | 29,648,161 | 29,649,084 | 22 | 0.08795856 | ZFP57 |