Table 1 Clinical and hormonal features of the patients with CPP
From: Methylome profiling of healthy and central precocious puberty girls
Family number | Initial clinical manifestation (age, y) | Time of diagnosis | BA (y) | LH (IU/L) | FSH (IU/L), Basal | E2 (pg/mL) | ||||
|---|---|---|---|---|---|---|---|---|---|---|
Age (y) | Breast Tanner stage | BMI (Z) | Basal | After GnRH | After leuprolide depot 3.75 mg | |||||
1 | Telarche (5.8) | 6.7 | 4 | 1.2 | 11 | 1.9 | 31.5 | NA | 6.2 | 53.3 |
2 | Telarche (7.7) | 8.2 | 3 | 0.09 | 11 | < 0.6 | NA | 17.6 | 4.2 | 31 |
3 | Telarche (5.5) | 8.1 | 3 | 0.17 | 11 | 1 | NA | 8.8 | 1.9 | 17.4 |
4 | Telarche (7.5) | 10.2 | 4 | 1.29 | 11 | 4.2 | NA | NA | NA | 98.8 |
5 | Telarche (7.3) | 8 | 3 | 1.28 | 11 | 1.5 | NA | 45.8 | 2.7 | < 13 |
6 | Telarche (6.6) | 7.3 | 4 | 1.41 | 9.5 | 0.1 | 16.9 | 16 | NA | < 13 |
7 | Telarche (5.5) | 7.1 | 3 | 0.11 | 7.8 | < 0.6 | NA | 6.5 | 1.5 | < 13 |
8 | Telarche (3) | 6.5 | 4 | 0.64 | 8.8 | < 0.6 | 4.2 | 9.8 | 3.7 | < 13 |
9 | Telarche (8) | 8 | 4 | − 0.09 | 10 | 0.1 | 6.9 | 4.6 | 2 | < 13 |
10 | Telarche (6.9) | 6.9 | 3 | 0.85 | 7.8 | 3.5 | 35 | NA | 5.2 | < 10 |