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Table 1 Clinical and hormonal features of the patients with CPP

From: Methylome profiling of healthy and central precocious puberty girls

Family number Initial clinical manifestation (age, y) Time of diagnosis BA (y) LH (IU/L) FSH (IU/L), Basal E2 (pg/mL)
Age (y) Breast Tanner stage BMI (Z) Basal After GnRH After leuprolide depot 3.75 mg
1 Telarche (5.8) 6.7 4 1.2 11 1.9 31.5 NA 6.2 53.3
2 Telarche (7.7) 8.2 3 0.09 11 < 0.6 NA 17.6 4.2 31
3 Telarche (5.5) 8.1 3 0.17 11 1 NA 8.8 1.9 17.4
4 Telarche (7.5) 10.2 4 1.29 11 4.2 NA NA NA 98.8
5 Telarche (7.3) 8 3 1.28 11 1.5 NA 45.8 2.7 < 13
6 Telarche (6.6) 7.3 4 1.41 9.5 0.1 16.9 16 NA < 13
7 Telarche (5.5) 7.1 3 0.11 7.8 < 0.6 NA 6.5 1.5 < 13
8 Telarche (3) 6.5 4 0.64 8.8 < 0.6 4.2 9.8 3.7 < 13
9 Telarche (8) 8 4 − 0.09 10 0.1 6.9 4.6 2 < 13
10 Telarche (6.9) 6.9 3 0.85 7.8 3.5 35 NA 5.2 < 10
  1. Abbreviations: BA bone age, BMI body mass index, E2 estradiol, NA not available, y years