Fig. 1

DNA methylation landscape in CF versus healthy controls. Recursively partitioned mixture model (RPMM) of the 10,000 CpGs (rows) with greatest sample variance across subjects. Individual samples 1–16 are shown in columns with sample status bar at the top: black (CF) and gray (healthy). Blue color represents increased sample methylation (a). RPMM determined the similarity of methylation among subjects resulting in two methylation classes L and R (b). Methylation class membership was associated with class status; inset contingency table depicts subject distribution in each class via a two-tailed Fisher’s exact test (P = 0.026)