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Fig. 5 | Clinical Epigenetics

Fig. 5

From: Comprehensive methylation analysis of imprinting-associated differentially methylated regions in colorectal cancer

Fig. 5

Cox proportional hazards regression analysis. a Model fitting summary. The prognosis score was computed as Z = − 2.011 × LOC728024 + 1.072 × RB1 – 1.187 × ZNF331-promoter. When aberrant methylation (hyper- or hypo-) at LOC728024, RB1, or ZNF331-promoter is found, the corresponding term is assigned a value of 1. coef: coefficient; se: standard error. z value = coef/se(coef). b Kaplan-Meier survival estimates. High prognostic scores (Z ≥ 0.332) were significantly associated with poor clinical prognosis compared low scores (Z < 0.332) (p = 0.0063, log-rank test, HR = 0.102 (95% CI 0.014–0.765))

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Clinical Epigenetics

ISSN: 1868-7083

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