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Table 6 Association of CD14 and HLA-DOA methylation (measured as percentage of methylated cytosine) with common colorectal carcinoma biomarkers (KRAS, BRAF, MSI)

From: Two histologically colorectal carcinomas subsets from the serrated pathway show different methylome signatures and diagnostic biomarkers

Biomarker*   CD14 HLA-DOA
  Median IR p value Median IR p value
KRAS Mutated 9.20 5.9   35.97 38.8  
  Wild-type 15.355 12 0.022 40.37 33.7 0.290
BRAF Mutated 16.68 21.7   39.63 35.5  
  Wild-type 12.845 6.4 0.035 37.53 36.2 0.82
MSI Unstable 16.7 19.1   40.95 30.2  
  Stable 11.32 6.1 0.001 31.9 39.6 0.069
  1. *Codon 12 and 13 mutations in KRAS and V600E mutation in BRAF were considered. CpG site 2 for CD14 and CpG site 2 for HLA-DOA were considered. Similar results were obtained for site 1 (data not shown)
  2. IR interquartile range, MSI microsatellite instability