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Table 6 Association of CD14 and HLA-DOA methylation (measured as percentage of methylated cytosine) with common colorectal carcinoma biomarkers (KRAS, BRAF, MSI)

From: Two histologically colorectal carcinomas subsets from the serrated pathway show different methylome signatures and diagnostic biomarkers

Biomarker*

 

CD14

HLA-DOA

 

Median

IR

p value

Median

IR

p value

KRAS

Mutated

9.20

5.9

 

35.97

38.8

 
 

Wild-type

15.355

12

0.022

40.37

33.7

0.290

BRAF

Mutated

16.68

21.7

 

39.63

35.5

 
 

Wild-type

12.845

6.4

0.035

37.53

36.2

0.82

MSI

Unstable

16.7

19.1

 

40.95

30.2

 
 

Stable

11.32

6.1

0.001

31.9

39.6

0.069

  1. *Codon 12 and 13 mutations in KRAS and V600E mutation in BRAF were considered. CpG site 2 for CD14 and CpG site 2 for HLA-DOA were considered. Similar results were obtained for site 1 (data not shown)
  2. IR interquartile range, MSI microsatellite instability
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Clinical Epigenetics

ISSN: 1868-7083

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