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Table 5 Immunohistochemical expression of CD14 and HLA-DOA proteins

From: Two histologically colorectal carcinomas subsets from the serrated pathway show different methylome signatures and diagnostic biomarkers

Protein Sample type n Distribution (A–C)
Intensity (1–3) score
Two-tier score p value (Fisher)
    A1 A3 B2 B3 C3 Negative/weak (A1-B2) Moderate/strong (B3-C3)  
CD14 SAC 26 11 10 0 3 2 21 (81.8) 5 (19.2)  
  hmMSI-H 21 3 6 0 5 7 9 (42.9) 12 (57.1) 0.008
HLA-DOA SAC 26 9 8 1 8 0 18 (69.2) 8 (30.8)  
  hmMSI-H 21 17 4 0 0 0 21 (100) 0 0.005
  1. Immunohistochemical markers in the tumours were evaluated by considering the distribution area score (A < one third, B = between one and two thirds, C = two-thirds-whole area) and the staining intensity (1 = none or weak staining, 2 = moderate, 3 = strong)
  2. SAC serrated adenocarcinoma, hmMSI-H-T colorectal carcinoma with histological and molecular high-level microsatellite instability