Two histologically colorectal carcinomas subsets from the serrated pathway show different methylome signatures and diagnostic biomarkers

Table 5 Immunohistochemical expression of CD14 and HLA-DOA proteins

Protein	Sample type	n	Distribution (A–C) Intensity (1–3) score					Two-tier score		p value (Fisher)
			A1	A3	B2	B3	C3	Negative/weak (A1-B2)	Moderate/strong (B3-C3)
CD14	SAC	26	11	10	0	3	2	21 (81.8)	5 (19.2)
	hmMSI-H	21	3	6	0	5	7	9 (42.9)	12 (57.1)	0.008
HLA-DOA	SAC	26	9	8	1	8	0	18 (69.2)	8 (30.8)
	hmMSI-H	21	17	4	0	0	0	21 (100)	0	0.005

Immunohistochemical markers in the tumours were evaluated by considering the distribution area score (A < one third, B = between one and two thirds, C = two-thirds-whole area) and the staining intensity (1 = none or weak staining, 2 = moderate, 3 = strong)
SAC serrated adenocarcinoma, hmMSI-H-T colorectal carcinoma with histological and molecular high-level microsatellite instability

ISSN: 1868-7083