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Table 3 Pyrosequencing for the relative quantitation of CpG methylation in CD14 and HLA-DOA genes

From: Two histologically colorectal carcinomas subsets from the serrated pathway show different methylome signatures and diagnostic biomarkers

Gene

 

CD14

HLA-DOA

CpG site

 

CpG1

CpG2

CpG1

CpG2

CpG3

SAC-T (n = 16)

Mean

6.89

13.56

33.83

34.95

89.78

 

SD

5.53

8.06

15.47

14.91

8.04

hMSI-H-T (n = 9)

Mean

13.64

22.38

50.94

48.12

94.61

 

SD

6.15

8.9

14.81

13.62

2.36

SAC-T vs. hmMSI-H

p value

0.010

0.020

0.013

0.039

0.14

SAC-N (n = 8)

Mean

7.97

13.86

60.02

58.27

100

 

SD

3.19

2.19

2.01

2.94

0

MSI-N (n = 6)

Mean

8.25

13.72

53.13

53.26

98.69

 

SD

2.36

2.37

6.73

8.92

2.75

SAC-T vs. SAC-N

p value

0.616

0.911

0.0001

0.0003

0.006

hmMSI-H-T vs. hmMSI-H-N

p value

0.064

0.038

0.742

0.432

0.002

SAC-N vs hmMSI-N

p value

0.860

0.911

0.017

0.159

0.271

  1. SAC-T tumoural tissue from serrated adenocarcinoma, hmMSI-H-T tumoural tissue from histological and molecular high-level microsatellite unstable colorectal carcinoma, SAC-N normal tissue adjacent to SAC, hmMSI-H-N normal tissue adjacent to hmMSI-H
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Clinical Epigenetics

ISSN: 1868-7083

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