Table 2 List of the 42 most differentially methylated genes (37 more methylated in hmMSI-H and 5 in SAC) as obtained from the array analysis
Gene symbol | >methyl. in | adj p val. | Gene name | Chr |
|---|---|---|---|---|
PDCD2L | hmMSI-H | 0.00101 | Programmed cell death 2-like | 19 |
FGFR2 | SAC | 0.00147 | Fibroblast growth factor receptor 2 | 10 |
CTSL2 | hmMSI-H | 0.00159 | Cathepsin L2 | 9 |
TLR4 | hmMSI-H | 0.00159 | Toll-like receptor 4 | 9 |
ANKRD10 | hmMSI-H | 0.00350 | Ankyrin repeat domain 10 | 13 |
COPZ1 | hmMSI-H | 0.00420 | Coatomer protein complex, subunit zeta 1 | 12 |
C17orf108 | SAC | 0.00420 | Chromosome 17 open reading frame 108 | 17 |
CEP68 | hmMSI-H | 0.00580 | Centrosomal protein 68 kDa | 2 |
ZNF652 | hmMSI-H | 0.00580 | Zinc finger protein 652 | 17 |
PCYOX1L | hmMSI-H | 0.00583 | Prenylcysteine oxidase 1 like | 5 |
GALNT11 | hmMSI-H | 0.00583 | UDP-NADG:polypeptide N-acetylgalactosaminyltransferase 11 | 7 |
MICAL2 | hmMSI-H | 0.00583 | Microtubule-associated monoxygenase, calponin and LIM domain 2 | 11 |
OSCP1 | hmMSI-H | 0.00583 | Organic solute carrier partner 1 | 1 |
ACAD10 | hmMSI-H | 0.00583 | Acyl-CoA dehydrogenase family, member 10 | 12 |
MELK | hmMSI-H | 0.00583 | Maternal embryonic leucine zipper kinase | 9 |
HLA-DOA | hmMSI-H | 0.00583 | Major histocompatibility complex, class II, DO alpha | 6 |
KRT20 | hmMSI-H | 0.00583 | Keratin 20 | 17 |
TMEM45B | hmMSI-H | 0.00583 | Transmembrane protein 45B | 11 |
LOC285401 | SAC | 0.00641 | Uncharacterized LOC285401 | 3 |
PPIL1 | hmMSI-H | 0.00650 | Peptidylprolyl isomerase (cyclophilin)-like 1 | 6 |
CA13 | hmMSI-H | 0.00709 | Carbonic anhydrase XIII | 8 |
BCL7C | hmMSI-H | 0.00709 | B cell CLL/lymphoma 7C | 16 |
CD14 | hmMSI-H | 0.00850 | CD14 molecule | 5 |
PLA2G4C | hmMSI-H | 0.00905 | Phospholipase A2, group IVC (cytosolic, calcium-independent) | 19 |
LY6G6D | hmMSI-H | 0.00908 | Lymphocyte antigen 6 complex, locus G6D | 6 |
TCF7L2 | hmMSI-H | 0.00954 | Transcription factor 7-like 2 (T-cell specific, HMG-box) | 10 |
RP11-165H20.1 | hmMSI-H | 0.00954 | CHIA-like pseudogene | 1 |
CHD6 | hmMSI-H | 0.00954 | Chromodomain helicase DNA-binding protein 6 | 20 |
PARN | hmMSI-H | 0.00954 | Poly(A)-specific ribonuclease | 16 |
KCNK15 | hmMSI-H | 0.00954 | Potassium channel, subfamily K, member 15 | 20 |
TMEM209 | hmMSI-H | 0.01015 | Transmembrane protein 209 | 7 |
GOLM1 | hmMSI-H | 0.01016 | Golgi membrane protein 1 | 9 |
ARRDC1 | hmMSI-H | 0.01016 | Arrestin domain containing 1 | 9 |
TRIM21 | hmMSI-H | 0.01016 | Tripartite motif containing 21 | 11 |
PHAX | hmMSI-H | 0.01016 | Phosphorylated adaptor for RNA export | 5 |
NMT2 | hmMSI-H | 0.01016 | N-myristoyltransferase 2 | 10 |
ATP12A | hmMSI-H | 0.01016 | ATPase, H+/K+ transporting, nongastric, alpha polypeptide | 13 |
ARHGAP30 | SAC | 0.01016 | Rho GTPase-activating protein 30 | 1 |
WWP1 | hmMSI-H | 0.01055 | WW domain-containing E3 ubiquitin protein ligase 1 | 8 |
GNAI3 | hmMSI-H | 0.01055 | Guanine nucleotide binding (G protein), α inhibit polypeptide 3 | 1 |
CD48 | SAC | 0.01055 | CD48 molecule | 1 |
EXPH5 | hmMSI-H | 0.01070 | Exophilin 5 | 11 |