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Fig. 5 | Clinical Epigenetics

Fig. 5

From: Epigenetic silencing of TMEM176A activates ERK signaling in human hepatocellular carcinoma

Fig. 5

TMEM176A suppresses human HCC cell xenograft growth in mice. a Representative tumors from TMEM176A unexpressed and TMEM176A re-expressed LM3 cell xenografts. b Tumor growth curves of TMEM176A unexpressed and TMEM176A re-expressed LM3 cells. ***P < 0.001. c Tumor weights in nude mice at the 24th day after inoculation of unexpressed and TMEM176A re-expressed LM3 cells. Bars: mean of five mice. ***P < 0.001. d Images of hematoxylin and eosin staining show tumors from TMEM176A unexpressed and TMEM176A re-expressed LM3 xenograft mice. IHC staining reveals the expression levels of TMEM176A, MMP2, MMP9, and SAR1A in TMEM176A unexpressed and TMEM176A re-expressed LM3 cell xenografts. Clinical specimens of low and high expression of TMEM176A were stained for SAR1A (× 400)

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